Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?

BMC Immunology

Table 1 Average Salmonella and TMEV titers (+/- SE) for female P₀, F₁ and F₂ mice.

Generation	Sample Size	MHC Genotype	Salmonella titers (10² CFU/spleen)	TMEV titers (10² PFU/spcd)
P₀	6	b/b	51.93 +/- 6.60	1.33 +/- 1.09
F₁	8	b/q	6.60 +/- 0.83	0.97 +/- 0.41
P₀	7	q/q	13.09 +/- 3.27 ^a	126.75 +/- 32.75
F₂	7	b/b	140.49 +/- 38.87	4.00 +/- 2.63
F₂	7	b/q	6.34 +/- 1.58	3.21 +/- 1.99
F₂	6	q/q	5.67 +/- 2.00 ^a	52.08 +/- 16.63
P₀	7	d/d	10.57 +/- 1.21	4.29 +/- 3.55
F₁	7	d/q	7.23 +/- 1.80	11.25 +/- 6.04
P₀	6	q/q	10.53 +/- 3.60 ^c	331.92 +/- 180.16 ^b
F₂	4	d/d	9.05 +/- 1.19	3.81 +/- 3.40
F₂	10	d/q	14.00 +/- 4.11	6.15 +/- 1.76
F₂	5	q/q	4.16 +/- 0.85 ^c	13.65 +/- 8.98 ^b

spcd = spinal cord; Comparisons in bold are significantly different as follows: ^a (F(1,35) = 7.127, p = 0.01); ^b (F(1,33) = 5.84, p = 0.02); ^c marginally significant (F(1,33) = 3.02, p = 0.09).

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