Figure 1
From: Characterization and phylogenetic epitope mapping of CD38 ADPR cyclase in the cynomolgus macaque
Cynomologus macaque CD38 cDNA, promoter and 5' end of intron 1. A. Primers used to clone the cDNA are wavy-underlined. Members of the 12-cysteine array of the ectodomain are color-boxed; cysteines that pair in disulfide formation are boxed in the same color. Differences in the human CD38 amino acid sequence are indicated under the macaque sequence. The transmembrane domain is underlined and glycosylation sites indicated. The sequence accession number is AY555148. B. Nucleotide sequence of the CD38 promoter from Macaca fascicularis (MFA) (Acc. No. AY622999), Homo sapiens (HSA) (Acc. No. AF001985) and Pan troglodytes (PTA) (Acc. No. AY623001). The nucleotide sequences begin at -1 immediately upstream of the ATG initiation codon. Potential transcription regulatory motifs common to the 3 species, identified with TRANSFAC® [62], are boxed and the relevant transcription factor indicated above. C. 5' end of intron 1 of macaque and human CD38, Acc. No. AY623000 and AF088883, respectively.