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Figure 5 | BMC Immunology

Figure 5

From: Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells

Figure 5

Signaling through EphA receptors reduces the stimulatory capacity of LLDC to activate CD4+T cells The indicated numbers of antigen presenting cells were used to stimulate 50000 CD4+ cells in the presence of immobilized control fusion protein (CD19-FC, open columns) or ephrin-A4-Fc (filled column). T cell proliferation was measured by 3H-thymidine incorporation on day 6–7. One of at least three representative experiments is shown here, the values are the mean of triplicates with the SD indicated. (A) An allogeneic presenting assay with LLDC (LLDC). (B) An allogeneic presenting assay with monocyte derived dendritic cells (DC). (C) An autologous antigen-presenting assay with LLDC (LLDC) pulsed with tuberculosis PPD antigen.

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