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Table 1 Expression of differentiation and activation markers on re-stimulated CD4+ cells

From: Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells

 

IFN-g, % pos

IL4, % pos

CD25, % pos

CD19-Fc, 1:100

3.0

2.3

10.3

ephrin-A4-Fc, 1:100

1.9

1.4

6.1

CD19-Fc, 1:10

10.2

2.6

19.3

ephrin-A4-Fc, 1:10

7.4

2.1

17.3

  1. The reduction in T cell proliferation is not a result of a change in the Th1/Th2 ratio, but rather a general reduction in the activation status of the T cells. Resting CD4+ cells were stimulated one week with LLDC, in the presence of immobilized control protein or ligand, and re-stimulated 5 hours with TPA and ionomycin. One of three representative experiments is shown, and data represent percent of living cells staining the indicated antibody.