Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes

Table 4 Differences in occurrence of transitions/transversion and mutations in two DNA strands of the CAN1 gene in wild-type and ung1 strains.

Spectra compared	wild-type	ung1	P_fisher
Variables
Transitions at G-C bases	56	61
Transversions at G-C bases	8	1	0.032
Transcribed strand (G→A)	19	37
Non-transcribed strand (C→T)	37	24	0.005

P_fisheris the probability that a 2 × 2 contingency table is homogeneous as calculated using Fisher exact test.

ISSN: 1471-2172