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Figure 1 | BMC Immunology

Figure 1

From: Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors

Figure 1

Alignment of p53 (PDB ID:1YCS; 1YCS_A d1) with p65 (PDB ID:1IKN; 1IKN_A d1). A. The structures of p53 molecule (taken from the crystal structure of p53 and p53 binding protein 2); B. The aligned structures of p53 and p65; C. The structure of the Rel homology domain of p65 (taken from the crystal structure of the p65/p50 heterodimer bound to IκBα); D. The aligned structures were colored according to information content based on a BLOSUM62 matrix to calculate conservation using the public domain program CN3D4.1 [70]. A spectrum of red to blue is used to denote the degree of conservation where red is the most conserved. E. The sequence alignment of p53 and p65 is depicted using the same coloring scheme as in the structure alignment in 1D.

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