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Table 2 LPS-induced CCL2, CXCL8 and TNFα secretion in TB patients

From: Elevated ex vivo monocyte chemotactic protein-1 (CCL2) in pulmonary as compared with extra-pulmonary tuberculosis

Chemo/cytokines pg/ml Median (range)

Group

Time (h)

ΔCCL2

ΔCXCL8

ΔTNFα

EC (N = 12)

18

754 (17–3058)

1712 (788–2786)

*3 1153 (0–1489)

 

48

1881 (713–7164)

1996 (1823–2977)

625 (211–858)

Pul (N = 10)

18

*1 1218 (765–2254)

1175 (318–2770)

*3,4 2154 (1244–4852)

 

48

*2 3398 (1643–7012)

1190 (0–3249)

957 (74–1869)

E-Pul (N = 8)

18

*1 33 (0–818)

727 (0–1219)

*4 577 (0–2180)

 

48

*2 32 (0–1194)

915 (0–1574)

73 (0–1821)

  1. All values are 'Δ' after baseline subtraction of CCL2, CXCL8 or TNFα from each group. Pair-wise analysis was carried out to determine differences between groups using Mann-Whitney – U test '*' P ≤ 0.05. '1–4' defines pairs of values that were statistically significant from each other; Endemic controls (EC), Pul-TB (pulmonary tuberculosis), EPul-TB (extra-pulmonary tuberculosis).