Figure 1

Reduction by oATP (used at the doses of 50, 100 and 200 μM, dissolved in 0.15 ml saline) of inflammatory pain in rat paws, as measured by paw withdrawal latency to a radiant heat stimulus, following the administration of carrageenan. Results are expressed as the mean ± SEM with n = 7 rats per group. * p < 0.05 compared with dose 0; ^ p < 0.05 compared with local administration at the same dose. All values were significantly higher in oATP-treated paws (circle) than in saline-treated paws (triangle).