Table 1 Immunohistochemical results in rat hind paws after induction of inflammation by carrageenan
Treatment | P2X7 receptor nerve expression | P2X7 receptor vascular expression | P2X7 receptor expression in lympho-histiocytic cells | Quantity of macrophages (HIS36+) |
|---|---|---|---|---|
Saline only | Strong | Strong | Weak | Very few |
Carrageenan only | Strong, locally moderate | Strong, focally moderate | Weak | Focally in discrete amount |
Carrageenan + OATP intraplantar injection | Moderate to weak | Moderate to weak | Weak to moderate | Few |
Carrageenan + oATP intravenous administration | Weak to absent | Very weak (absent in area close to inflammatory infiltrate) | Moderate, focally strong | Few |