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Figure 1 | BMC Immunology

Figure 1

From: Reciprocal role of cyclins and cyclin kinase inhibitor p21WAF1/CIP1 on lymphocyte proliferation, allo-immune activation and inflammation

Figure 1

CsA inhibits cyclins, IL-6 and TNF-α and induces p21WAF1/CIP1 mRNA expression in activated lymphocytes. A). A picture representative of three different experiments demonstrating cyclins (D3 and G), p21WAF1/CIP1, IL-6, TNF-α and induction of mRNA expression in activated lymphocytes (lane 2) with CsA (lanes 3). The lower bands in IL-2 mRNA area are primer dimers. B) Mean ± SEM (n = 3) of the ratio of cyclins, IL-6 and TNF-α and induces p21WAF1/CIP1 with β-actin is shown for lymphocytes either unctivated or activated with and without CsA. The p values signify the statistical significance for mRNA expression in lymphocytes activated with and with out CsA for each gene. C) Western blot analysis for p21 protein in lymphocytes unctivated (lane 1), activated (lane 2) with CsA (lane 3).

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BMC Immunology

ISSN: 1471-2172

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