Figure 5

Heterotypic B-cell rosetting and emperipolesis. Primary FDC-like cells at day 14 were co-cultured with B-cells (Raji) at a ratio of 1:1 for 4 hours, fixed and double-stained for AP and CD22. a, AP^pos FDC-like cells (blue) with filamentous dendrites capturing CD22⁺ Raji cells (brown); b, survey of rosettes and various stages of emperipolesis.