TY - JOUR AU - Yang, Jiwei AU - Rosen, Steven D. AU - Bendele, Philip AU - Hemmerich, Stefan PY - 2006 DA - 2006/06/13 TI - Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis JO - BMC Immunology SP - 12 VL - 7 IS - 1 AB - Leukocyte recruitment across blood vessels is fundamental to immune surveillance and inflammation. Lymphocyte homing to peripheral lymph nodes is mediated by the adhesion molecule, L-selectin, which binds to sulfated carbohydrate ligands on high endothelial venules (HEV). These glycoprotein ligands are collectively known as peripheral node addressin (PNAd), as defined by the function-blocking monoclonal antibody known as MECA-79. The sulfation of these ligands depends on the action of two HEV-expressed N-acetylglucosamine 6-O-sulfotransferases: GlcNAc6ST-2 and to a lesser degree GlcNAc6ST-1. Induction of PNAd has also been shown to occur in a number of human inflammatory diseases including rheumatoid arthritis (RA). SN - 1471-2172 UR - https://doi.org/10.1186/1471-2172-7-12 DO - 10.1186/1471-2172-7-12 ID - Yang2006 ER -