Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis

BMC Immunology

Table 1 mRNA expression of Wnt ligands 1–19, Fzd receptors 1–10, Wnt antagonists sFRP1-4, WIF1, Dkk1 and Dkk4

	BM B progenitor cells	BM stromal cells (BMS)	Human fetal brain		BM B progenitor cells	BM stromal cells (BMS)	Human fetal brain
Wnt1	+/-	-	+	Fzd1	+/-	-	-
Wnt2	-	-	+	Fzd2	+	-	+
Wnt2B	+	+	+	Fzd3	+	+	+
Wnt3	-	-	+	Fzd4	+	+	+
Wnt3A	+/-	-	-	Fzd5	+	-	+
Wnt4	+/-	-	+	Fzd6	+	+	+
Wnt5A	+/-	+	+	Fzd7	+/-	-	+
Wnt5B	+	+	+	Fzd8	ND	-	ND
Wnt6	ND	-	ND	Fzd9	+	-	+
Wnt7A	-	-	+	Fzd10	-	-	-
Wnt7B	-	-	+	Dkk1	+	+	+
Wnt8A	+	-	+	Dkk4	+	-	-
Wnt8B	ND	+	ND	sFRP1	-	-	+
Wnt9A	+/-	-	+	sFRP2	+/-	+	+
Wnt9B	+/-	+	+	sFRP3	+/-	+	+
Wnt10A	+	-	-	sFRP4	+	-	+
Wnt10B	+/-	-	+	WIF1	+	ND	+
Wnt11	+/-	-	+
Wnt16	+	-	+

Genes expressed (+), not expressed (-), variably expressed between experiments(+/-), not determined (ND). N = 2. BM B progenitor cells: CD10⁺IgM^-CD45⁺ cells sorted by FACS and pooled from three different donors. Total RNA from human fetal brain was used as control.

ISSN: 1471-2172