Figure 4
From: Sexual dimorphism in immune response genes as a function of puberty
Immunoglobulin isotypes, Fas, and FasL genes show similar expression patterns. Nucleating hierarchical clustering with IgG1 and IgG2b revealed Fas and FasL as co-regulated transcripts in post-pubertal female mouse spleens. These data drove the hypothesis that a non-apoptotic role of Fas/FasL might be responsible for downstream differential IgG isotype expression. The X-axis represents time points (weeks) in female and male mice, and the Y-axis represents relative intensity ratios.