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Table 3 TLR ligand-induced cytokine/chemokine production in post-pubertal mice shows sexual dimorphism.

From: Sexual dimorphism in immune response genes as a function of puberty

TLR ligand Cytokine/Chemokine Male (pg/ml) Female (pg/ml)
Media IL-1α 2.6 ± 0.5 3.8 ± 0.8
  IL-1β 7.2 ± 2.3 6.5 ± 1.3
  IL-6 39.7 ± 4.1 39.4 ± 10.2
  IL-10 20.2 ± 3.5 27 ± 2.8
  IL-12 4.1 ± 1.4 4.7 ± 1.1
  IL-18 80.1 ± 17.2 46 ± 11.2
  MCP-1 3.7 ± 0.4 17.3 ± 5.8*
  RANTES 159.2 ± 56.5 171.4 ± 54.2
LPS IL-1α 24.5 ± 1.8 24.8 ± 5.2
  IL-1β 29.1 ± 4.1 23.8 ± 3.6
  IL-6 848.7 ± 154.4 1132.7 ± 323
  IL-10 1484.5 ± 56.2 1960.5 ± 316.4
  IL-12 12.7 ± 1.0 13.3 ± 1.1
  IL-18 150.8 ± 10.8 151.8 ± 23.9
  MCP-1 14.8 ± 2.7 21.2 ± 4.4
  RANTES 937.5 ± 369.8 1202.3 ± 567.4
LTA IL-1α 21.9 ± 0.9* 14.6 ± 2.2
  IL-1β 25.3 ± 4.3* 11.9 ± 2.7
  IL-6 214.2 ± 36.1 174.2 ± 48.3
  IL-10 199.1 ± 21.3 210.7 ± 43.8
  IL-12 9.5 ± 1.3 7.4 ± 0.5
  IL-18 118.3 ± 6.0 94.1 ± 16.7
  MCP-1 26.5 ± 3 32.2 ± 7.5
  RANTES 675.0 ± 228.5 772.4 ± 323.6
Poly I:C IL-1α 24.2 ± 1.9 20.0 ± 3.0
  IL-1β 20.7 ± 2.1 13.8 ± 3.7
  IL-6 201.4 ± 36.7 192.2 ± 45.59
  IL-10 257.6 ± 17.8 298.1 ± 37.8
  IL-12 6.7 ± 0.5 7.5 ± 0.5
  IL-18 92.6 ± 12.2 105.8 ± 18.0
  MCP-1 24.6 ± 2.3 31.3 ± 7.1
  RANTES 644.4 ± 236.3 980.7 ± 362.3
Imiquimod IL-1α 5.9 ± 0.8 7.3 ± 0.7
  IL-1β 29.4 ± 7.2 28.2 ± 1.5
  IL-6 4831.3 ± 1210.29 5256.1 ± 881.4
  IL-10 1232.3 ± 272.3 1578.7 ± 145.9
  IL-12 12.9 ± 1.7 14.5 ± 1.6
  IL-18 137.1 ± 19.8 136.3 ± 15.0
  MCP-1 28.6 ± 4.5 65.6 ± 13.9*
  RANTES 632.1 ± 292.6 679.2 ± 273.1
Pam3CSK4 IL-1α 10.3 ± 6.9 3.2 ± 0.4
  IL-1β 12.5 ± 3.5 6.5 ± 0.2
  IL-6 272.9 ± 29.6 262.6 ± 59.4
  IL-10 295.3 ± 30.6 351.8 ± 38.5
  IL-12 5.4 ± 1.1 6.6 ± 1.2
  IL-18 47.8 ± 17.0 80.9 ± 14.8
  MCP-1 15.7 ± 1.4 40.2 ± 12.5
  RANTES 195.7 ± 68.3 279.2 ± 94.0
T1 CpG IL-1α 3.5 ± 1.0 3.5 ± 0.7
  IL-1β 9.5 ± 2.2 7.7 ± 1.5
  IL-6 169.5 ± 21 279.2 ± 44.7*
  IL-10 51.5 ± 9.8 80.6 ± 10.5*
  IL-12 6.0 ± 0.6 7.2 ± 1.2
  IL-18 58.4 ± 7.1 96.5 ± 18.0
  MCP-1 9.6 ± 3.1 43.5 ± 12.1*
  RANTES 403.4 ± 158.7 619.3 ± 218.3
  1. *Indicates statistical signifigance (p < 0.05)