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Figure 6 | BMC Immunology

Figure 6

From: Expression of P2 receptors in human B cells and Epstein-Barr virus-transformed lymphoblastoid cell lines

Figure 6

Comparison of ATP-induced increases in [Ca2+] i in B cells and LCLs. (A, B) Average time courses for Ca2+ responses to P2 receptor stimulation with ATP (1 mM) in B cells (A, n = 6) and in LCLs (B, n = 6). ATP was applied as indicated by the horizontal bars above the traces. (C) Concentration-response curve for the increase in [Ca2+]i in response to ATP in B cells and in LCLs (Δratio F340/F380). ATP increased [Ca2+]i in a dose-dependent manner. The maximum increase in the [Ca2+]i over basal is plotted against the concentration of ATP. The measurement of [Ca2+]i was carried out in single cells attached to a coverslip, as described in the Methods section. Data are the mean ± SEM for at least 25 cells on 4 to 5 coverslips.

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