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Figure 4 | BMC Immunology

Figure 4

From: Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes

Figure 4

Kinetics of ATRA-induced IL-5 production and inhibition of IFN-(synthesis post activation of CD4+ T cells. IL-5 and IFN-(proteins were quantitated by ELISA in supernatants of CD4+ T cells cultured (1 × 106 ml) with immobilized anti-CD3 mAb (200 ng/ml) and anti-CD28 (1 μg/ml) and treated with ETOH (-) or ATRA 10-7 M (+) for 12, 24 or 48 h. Data from 8 independent experiments is shown here. A paired T test was performed on donor T cell values from each time period as described in the Methods. The results are expressed as pg/ml for IL-5 and ng/ml for IFN-(.

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