Figure 5

Consensus amino acid comparisons of V _H 4 sequences encoding IgM xenoantibodies. MMU57583 (top line) is a GenBank® macaque gene with high percent identity to many of the rhesus V_H4 sequences. IGHV4-59 (second line) is the V_H4 family gene shown to be increased post-pig cell exposure in a human BAL study. DP71 (third line) is an allele of IGHV4-59 to which many of the rhesus V_H4 sequences match with high percent similarity. Consensus rhesus V_H4 sequences at both days 0 and 14 show 89 to 92% nucleic acid sequence identity to DP71. * = residue is identical to one immediately above.