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Table 1 T cell sub-populations in mAb treated mice. FACS analysis of splenocytes collected from untreated and antibody-treated CBA mice (1 mg YTS177 and 1 mg YTS105 ip given on days -28, -26 and -24 relative to data collection on day 0). 'Total splenocytes' refers to all cells in the lymphocyte forward- and side-scatter gate. NS (not significant) p > 0.05; (**) p < 0.001.

From: Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning

Cell phenotype Untreated, n= 6(mean +/- SD)% AntiCD4 + antiCD8 treated, n 6 (mean +/- SD)% p value
(CD3+CD8+/total splenocytes) 20.8 +/- 2.6 1.8 +/- 0.6 **
# (CD44+ /CD8+) 6.9 +/- 0.8 36.7 +/- 6.4 **
(CD3+CD4+ /total splenocytes) 32.0 +/- 6.2 37.8 +/- 6.2 NS
# (CD25+ /CD4+) 11.1 +/- 0.7 13.8 +/- 1.0 **
# (CD44+ /CD4+) 8.1 +/- 1.0 14.4 +/- 1.6 **
  1. # Only gated CD3+ cells were taken into account for these calculations