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Table 2 IC50 values for the inhibition of cytokine protein synthesis by CsA in ABL and CBL

From: Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors

Cytokine

CBL (nM)

ABL (nM)

IL-2

4.52 ± 0.70

3.36 ± 0.13

IFNγ

4.32 ± 0.89

12.60 ± 5.05

IL-4

3.43 ± 0.68

3.71 ± 0.16

IL-5

3.27 ± 0.91

4.73 ± 1.23

IL-13

4.42 ± 0.67

3.74 ± 0.06

IL-3

3.20 ± 0.41

5.56 ± 1.03

GM-CSF

7.75 ± 0.53

9.02 ± 0.44

  1. Cells were stimulated by TPA/ionomycin for 24 hrs. Protein levels were determined in the supernatant by ELISA. Data shown are mean IC50 ± standard error for 3 donors.