Figure 6
From: Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
Stimulation of pDC with 3M-852A and 3M-011 results in increased expression of a large number of chemokines. Protein-interaction network was generated for expression changes in pDC 4 hr post stimulation with 3M-852A and 3M-011. The network was generated using a list of genes in the GO function classification of chemokines and the shortest path algorithm. The network summarizes interactions between chemokines increased in expression and their respective receptors. Green arrows indicate binding interactions or covalent modifications that result in activation or increased transcription. Red arrows indicate binding interactions or covalent modifications that result in inhibition of activity or suppression of transcription.