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Figure 8 | BMC Immunology

Figure 8

From: Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists

Figure 8

Stimulation of pDC with 3M-852A and 3M-011 results in the induction of an anti-apoptotic gene expression program. Protein-interaction network was generated for expression changes in pDC 4 hr post stimulation with 3M-852A and 3M-011. The network was generated from a list of genes with GO process classification of anti-apoptosis, using the shortest path algorithm. The network highlights the large number of anti-apoptotic genes that are increased in expression with a concomitant decrease in expression of key pro-apoptotic genes including several that are transscriptionally regulated by p53. Remaining network details are as described in Figure 6.

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