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Table 1 List of 66 genes with the largest log fold changes between CD146 positive and CD146 negative T cells.

From: A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile

Rank Gene Fold Increase (or decrease) CD3+CD146+/CD3+CD146- Function* Process*
1 Dual specificity phosphatase 4 65 Protein phosphatase activity Signal transduction/cell communication
2. Regulator of G-protein signaling 1 41.8 GTPase activator Signal transduction/cell communication
3 Nuclear receptor subfamily 4, group A member 2 35.7 Ligand-dependent nuclear receptor Signal transduction/cell communication
4 v-jun sarcoma virus 17 oncogene homolog 22.5 _ _
5 Kruppel-like factor 10 22.3 Transcription factor activity Regulation of nucleobase, nucleoside metabolism
6 Chromosome 10 open reading frame 128 20.6 Unknown Unknown
7 Dual specificity phosphatase 1 19.9 Protein phosphatase activity Signal transduction/cell communication
8 Interleukin 8 19.1 Cytokine Immune response
9 RAR-related orphan receptor C 18.1 Ligand-dependent nuclear receptor Regulation of nucleobase, nucleoside metabolism
10 Family with sequence similarity 46, member C 15 Unknown Unknown
11 FBJ murine osteosarcoma viral oncogene homolog B 13.6 Transcription factor activity Regulation of nucleobase, nucleoside metabolism
12 Pre-B-cell colony enhancing factor 1 12.3 Cytokine Signal transduction/cell communication
13 A kinase (PRKA) anchor protein 2 11.9 Cytoskeletal anchor Cell growth and/or maintenance
14 Pellino homolog 1 11.5 Receptor signaling complex scaffold activity Signal transduction/cell communication
15 Chimerin1 11.1 GTPase activator activity Signal transduction/cell communication
16 Solute carrier family 6, neurotransmitter transporter, GABA, member 13 10.7 Auxiliary transport protein activity Transport
17 Tribbles homolog 1 10.4 Protein kinase activity Signal transduction/cell communication
18 Integrin beta 1 (fibronectin receptor) 9.7 Receptor activity Signal transduction/cell communication
19 Rho GTPase activating protein 10 9.6 GTPase activator activity Signal transduction/cell communication
20 Phorbol-12-myristate-13-acetate-induced protein 1 9.5 Unknown Apoptosis
21 Tumor necrosis factor alpha-induced protein 3 9.3 Transcription regulator activity Regulation of nucleobase, nucleoside metabolism
22 CD83 antigen 9.2 Unknown Immune response
23 DEAD (asp-Glu-Ala-Asp) box polypeptide 31 8.6 RNA binding Regulation of nucleobase, nucleoside metabolism
24 Similar to RIKEN cDNA 1200014N16 gene 8.2 Unknown Unknown
25 Cyclin L1 8.2 RNA binding Regulation of nucleobase, nucleoside metabolism
26 Alpha thalassemia/mental retardation syndrome X-linked 7.9 _ _
27 Pvt1 oncogene homolog, MYC activator 7.7 _ _
28 SNF1-like kinase 7.7 Protein kinase activity Signal transduction/cell communication
29 Basic helix-loop-helix domain containing class B, 2 7.6 Transcription regulator activity Regulation of nucleobase, nucleoside metabolism
30 Phytoceramidase, alkaline 7.6 Hydrolase activity Metabolism;energy pathways
31 BTG family, member 3 7.4 Regulation of cell cycle Signal transduction/cell communication
32 Runt-related transcription factor 1 7.4 Transcription factor activity Regulation of nucleobase, nucleoside metabolism
33 Phosphodiesterase 4D, c-AMP-specific 7.2 Phosphoric diester hydrolase activity Signal transduction/cell communication
34 SKI-like 7.2 unknown Signal transduction/cell communication
35 DEAD (asp-Glu-Ala-Asp) box polypeptide 59 7.2 RNA binding Regulation of nucleobase, nucleoside metabolism
36 Dynamin 3 7.1 GTPase activity Signal transduction/cell communication
37 Interferon-related Developmental regulator 1 7.1 Receptor binding Signal transduction/cell communication
38 Bicaudal D homolog 1 7 Transporter activity Transport
39 Melanoma cell adhesion molecule 7 Cell adhesion molecule Signal transduction/cell communication
40 Clone IMAGE: 110218 mRNA sequence 6.9 _ _
41 Trophoblast-derived noncoding RNA 6.9 _ _
42 CDNA clone IMAGE: 4077090, partial cds 6.7 _ _
43 Hydroprostaglandin dehydrogenase 15-(NAD) 6.6   
44 PERP, TP53 apoptosis effector 6.5 Unknown Apoptosis
45 Hypothetical protein MGC14376 6.4 Unknown Unknown
46 Interleukin 1 receptor, type 1 6.2 Transmembrane receptor activity Signal transduction/cell communication
47 Ring finger protein 10 6.1 Ubiquitin-specific protease activity Protein metabolism
48 Protein phosphatase 2, regulatory subunit B(B56) gamma isoform 6 _ _
49 Protein tyrosine phosphatase, non-receptor type 13 6 Protein tyrosine phosphatase activity Signal transduction/cell communication
50 v-ets erythroblastosis virus E26 oncogene homolog 1 5.9 Transcription factor activity Regulation of nucleobase, nucleoside metabolism
51 DKFZP586A0522 protein 5.8 Methyltransferase activity Metabolism; energy pathways
52 Similar to echinoderm microtubule associated protein like 5 5.8 _ _
53 Hypothetical protein FLJ43663 5.8 Unknown Unknown
54 Deleted in lymphocytic leukemia, 2 5.8 Unknown Cell growth and/or maintenance
55 CDNA clone IMAGE: 3542720 5.8 - -
56 Tetratricopeptide repeat domain 8 5.6 Unknown Cell growth and/or maintenance
57 DNA polymerase-transactivated protein 6 5.6 Unknown Unknown
-9 Ribosomal protein S11 1/5.6 Ribosomal subunit Protein metabolism
-8 Ribosomal protein S9 1/6.2 Ribosomal subunit Protein metabolism
-7 Hypothetical protein MGC40157 1/6.2 Unknown Unknown
-6 Chemokine (C-C motif) receptor 7 1/6.3 G coupled protein receptor Signal transduction/cell communication
-5 ATPase, H+ transporting lysosomal 9 kDa, V0 subunit e 1/6.5 ATPase activity Transport
-4 Ribosomal protein L28 1/6.6 Ribosomal subunit Protein metabolism
-3 Nitric oxide synthase interacting protein 1/7.3 Transporter activity Transport
-2 CD8 antigen, beta polypeptide 1 1/7.7 T cell receptor activity Immune response
-1 Hypothetical protein FLJ14346 1/8.5 Unknown Unknown
  1. *from the Human Protein Reference Database http://www.hprd.org