Table 1 List of 66 genes with the largest log fold changes between CD146 positive and CD146 negative T cells.
Rank | Gene | Fold Increase (or decrease) CD3+CD146+/CD3+CD146- | Function* | Process* |
|---|---|---|---|---|
1 | Dual specificity phosphatase 4 | 65 | Protein phosphatase activity | Signal transduction/cell communication |
2. | Regulator of G-protein signaling 1 | 41.8 | GTPase activator | Signal transduction/cell communication |
3 | Nuclear receptor subfamily 4, group A member 2 | 35.7 | Ligand-dependent nuclear receptor | Signal transduction/cell communication |
4 | v-jun sarcoma virus 17 oncogene homolog | 22.5 | _ | _ |
5 | Kruppel-like factor 10 | 22.3 | Transcription factor activity | Regulation of nucleobase, nucleoside metabolism |
6 | Chromosome 10 open reading frame 128 | 20.6 | Unknown | Unknown |
7 | Dual specificity phosphatase 1 | 19.9 | Protein phosphatase activity | Signal transduction/cell communication |
8 | Interleukin 8 | 19.1 | Cytokine | Immune response |
9 | RAR-related orphan receptor C | 18.1 | Ligand-dependent nuclear receptor | Regulation of nucleobase, nucleoside metabolism |
10 | Family with sequence similarity 46, member C | 15 | Unknown | Unknown |
11 | FBJ murine osteosarcoma viral oncogene homolog B | 13.6 | Transcription factor activity | Regulation of nucleobase, nucleoside metabolism |
12 | Pre-B-cell colony enhancing factor 1 | 12.3 | Cytokine | Signal transduction/cell communication |
13 | A kinase (PRKA) anchor protein 2 | 11.9 | Cytoskeletal anchor | Cell growth and/or maintenance |
14 | Pellino homolog 1 | 11.5 | Receptor signaling complex scaffold activity | Signal transduction/cell communication |
15 | Chimerin1 | 11.1 | GTPase activator activity | Signal transduction/cell communication |
16 | Solute carrier family 6, neurotransmitter transporter, GABA, member 13 | 10.7 | Auxiliary transport protein activity | Transport |
17 | Tribbles homolog 1 | 10.4 | Protein kinase activity | Signal transduction/cell communication |
18 | Integrin beta 1 (fibronectin receptor) | 9.7 | Receptor activity | Signal transduction/cell communication |
19 | Rho GTPase activating protein 10 | 9.6 | GTPase activator activity | Signal transduction/cell communication |
20 | Phorbol-12-myristate-13-acetate-induced protein 1 | 9.5 | Unknown | Apoptosis |
21 | Tumor necrosis factor alpha-induced protein 3 | 9.3 | Transcription regulator activity | Regulation of nucleobase, nucleoside metabolism |
22 | CD83 antigen | 9.2 | Unknown | Immune response |
23 | DEAD (asp-Glu-Ala-Asp) box polypeptide 31 | 8.6 | RNA binding | Regulation of nucleobase, nucleoside metabolism |
24 | Similar to RIKEN cDNA 1200014N16 gene | 8.2 | Unknown | Unknown |
25 | Cyclin L1 | 8.2 | RNA binding | Regulation of nucleobase, nucleoside metabolism |
26 | Alpha thalassemia/mental retardation syndrome X-linked | 7.9 | _ | _ |
27 | Pvt1 oncogene homolog, MYC activator | 7.7 | _ | _ |
28 | SNF1-like kinase | 7.7 | Protein kinase activity | Signal transduction/cell communication |
29 | Basic helix-loop-helix domain containing class B, 2 | 7.6 | Transcription regulator activity | Regulation of nucleobase, nucleoside metabolism |
30 | Phytoceramidase, alkaline | 7.6 | Hydrolase activity | Metabolism;energy pathways |
31 | BTG family, member 3 | 7.4 | Regulation of cell cycle | Signal transduction/cell communication |
32 | Runt-related transcription factor 1 | 7.4 | Transcription factor activity | Regulation of nucleobase, nucleoside metabolism |
33 | Phosphodiesterase 4D, c-AMP-specific | 7.2 | Phosphoric diester hydrolase activity | Signal transduction/cell communication |
34 | SKI-like | 7.2 | unknown | Signal transduction/cell communication |
35 | DEAD (asp-Glu-Ala-Asp) box polypeptide 59 | 7.2 | RNA binding | Regulation of nucleobase, nucleoside metabolism |
36 | Dynamin 3 | 7.1 | GTPase activity | Signal transduction/cell communication |
37 | Interferon-related Developmental regulator 1 | 7.1 | Receptor binding | Signal transduction/cell communication |
38 | Bicaudal D homolog 1 | 7 | Transporter activity | Transport |
39 | Melanoma cell adhesion molecule | 7 | Cell adhesion molecule | Signal transduction/cell communication |
40 | Clone IMAGE: 110218 mRNA sequence | 6.9 | _ | _ |
41 | Trophoblast-derived noncoding RNA | 6.9 | _ | _ |
42 | CDNA clone IMAGE: 4077090, partial cds | 6.7 | _ | _ |
43 | Hydroprostaglandin dehydrogenase 15-(NAD) | 6.6 | ||
44 | PERP, TP53 apoptosis effector | 6.5 | Unknown | Apoptosis |
45 | Hypothetical protein MGC14376 | 6.4 | Unknown | Unknown |
46 | Interleukin 1 receptor, type 1 | 6.2 | Transmembrane receptor activity | Signal transduction/cell communication |
47 | Ring finger protein 10 | 6.1 | Ubiquitin-specific protease activity | Protein metabolism |
48 | Protein phosphatase 2, regulatory subunit B(B56) gamma isoform | 6 | _ | _ |
49 | Protein tyrosine phosphatase, non-receptor type 13 | 6 | Protein tyrosine phosphatase activity | Signal transduction/cell communication |
50 | v-ets erythroblastosis virus E26 oncogene homolog 1 | 5.9 | Transcription factor activity | Regulation of nucleobase, nucleoside metabolism |
51 | DKFZP586A0522 protein | 5.8 | Methyltransferase activity | Metabolism; energy pathways |
52 | Similar to echinoderm microtubule associated protein like 5 | 5.8 | _ | _ |
53 | Hypothetical protein FLJ43663 | 5.8 | Unknown | Unknown |
54 | Deleted in lymphocytic leukemia, 2 | 5.8 | Unknown | Cell growth and/or maintenance |
55 | CDNA clone IMAGE: 3542720 | 5.8 | - | - |
56 | Tetratricopeptide repeat domain 8 | 5.6 | Unknown | Cell growth and/or maintenance |
57 | DNA polymerase-transactivated protein 6 | 5.6 | Unknown | Unknown |
-9 | Ribosomal protein S11 | 1/5.6 | Ribosomal subunit | Protein metabolism |
-8 | Ribosomal protein S9 | 1/6.2 | Ribosomal subunit | Protein metabolism |
-7 | Hypothetical protein MGC40157 | 1/6.2 | Unknown | Unknown |
-6 | Chemokine (C-C motif) receptor 7 | 1/6.3 | G coupled protein receptor | Signal transduction/cell communication |
-5 | ATPase, H+ transporting lysosomal 9 kDa, V0 subunit e | 1/6.5 | ATPase activity | Transport |
-4 | Ribosomal protein L28 | 1/6.6 | Ribosomal subunit | Protein metabolism |
-3 | Nitric oxide synthase interacting protein | 1/7.3 | Transporter activity | Transport |
-2 | CD8 antigen, beta polypeptide 1 | 1/7.7 | T cell receptor activity | Immune response |
-1 | Hypothetical protein FLJ14346 | 1/8.5 | Unknown | Unknown |