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Figure 1 | BMC Immunology

Figure 1

From: Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens

Figure 1

Nucleotide sequences of the V H genes encoding xenoantibodies in the V H 4 family. The IGVH4-59 germline progenitor encodes a proportion of xenoantibodies in patients mounting active xenoantibody responses. Shown are the sequences of immunoglobulin genes encoding xenoantibodies in patients at day 10 after placement on a bioartificial liver containing porcine hepatocytes. (A.) The nucleic acid sequence of genes encoding xenoantibodies in the VH4 family are most closely related to the human VH4-59 germline gene.Stars indicate identities in nucleic acid sequence. Clone numbers are indicated in parenthesis. Nomenclature of the germline genes, alignments and numbering are based on the human immunoglobulin germline gene table [68]. (B.) Translated amino acid sequences of VH4 genes encoding xenoantibodies compared with the amino acid sequence of the closest human germline progenitor VH4-59.

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BMC Immunology

ISSN: 1471-2172

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