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Table 5 B pocket structures of reference panel alleles.

From: HLA class I supertypes: a revised and updated classification

Residues1 Key residues Reference panel allele(s) Associated supertype(s) Specificity
YDSVENIFNY DENIFNY B*0801-2 B08 Undefined
YFAVMEKVHC FMEKVHC A*0207 A02 Small and aliphatic
YFAVMEKVHF FMEKVHF A*0217 A02 Small and aliphatic
YFAVMEKVHY FMEKVHY A*0201-4 A02 Small and aliphatic
YFAVMENMHY FMENMHY A*0101 A01 Small and aliphatic
YFAVMENVHY FMENVHY A*3201, A*7401 A01 A03 Small and aliphatic
YFAVMENVQY FMENVQY A*0301 A03 Small and aliphatic
YHSVTEISNS HTEISNS B*3701 B44 Acidic
YHSVTNISNY HTNISNY B*1801 B44 Acidic
YHTVEEICKY HEEICKY B*2702-7, B*2709 B27 Basic
YHTVENICKY HENICKY B*7301 B27 Basic
YHTVKEISNY HKEISNY B*4001-2, B*4006, B*4501 B44 Acidic
YSAVMEKVHF SMEKVHF A*2301, A*2402 A24 Aromatic and aliphatic
YSAVMENVHY SMENVHY A*3002-4 A01 Small and aliphatic
YSAVMENVQY SMENVQY A*3001 A01 A03 Small and aliphatic
YTAVMENVHY TMENVHY A*3101 A03 Small and aliphatic
YTAVMNNVHY TMNNVHY A*3301, A*3303 A03 Small and aliphatic
YTAVMQNVQY TMQNVQY A*2902 A01 A24 Small, aliphatic and aromatic
YYAVENIYQY YENIYQY B*5501-2, B*5601 B07 Proline
YYAVGNIYQY YGNIYQY B*5401 B07 Proline
YYAVMEISNY YMEISNY B*1501, B*1512 B62 Aliphatic
YYAVMEKVHY YMEKVHY A*0205, A*0206, A*0214 A02 Small and aliphatic
YYAVMEKYQY YMEKYQY B*4601 B62 Aliphatic
YYAVMENMSY YMENMSY B*1516-17, B*5701-2 B58 Small
YYAVMENVQY YMENVQY A*1101 A03 Small and aliphatic
YYAVMNIFNY YMNIFNY B*1508 B07 Proline
YYAVMNISNY YMNISNY B*1502, B*1513 B62 Aliphatic
YYAVMNNVHY YMNNVHY A*2601-3 A01 Small and aliphatic
YYAVMNNVQY YMNNVQY A*6601, A*6801-2, A*6901 A02 A03 Small and aliphatic
YYAVTEISNY YTEISNY B*5201 B62 Aliphatic
YYAVTENMSY YTENMSY B*5801-2 B58 Small
YYAVTNIFNY YTNIFNY B*3501, B*3503, B*5101-3, B*5301, B*7801 B07 Proline
YYSVEEISNY YEEISNY B*1503, B*3902, B*4801 B27 Basic
YYSVENICNS YENICNS B*3909 B27 Basic
YYSVENICNY YENICNY B*1402, B*1509-10, B*1518, B*3801, B*3901 B27 Basic
YYSVENIYNY YENIYNY B*0703 B07 Proline
YYSVENIYQY YENIYQY B*0702, B*0705, B*4201, B*6701 B07 Proline
YYTVKEISNY YKEISNY B*4402-3 B44 Acidic
  1. 1. Based on data presented in Saper et al, and Madden (see Methods), the MHC residues utilized as constituting the B pocket are: 7, 9, 24, 34, 45, 63, 66, 67, 70, and 99. Key residues are those in positions 9, 45, 63, 66, 67, 70, and 99.