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Table 6 F pocket structures of reference panel alleles.

From: HLA class I supertypes: a revised and updated classification

Residues1 Key residues2 Reference panel allele(s) Associated supertype(s) Specificity
DDTLYIIEHYWTKW DTLH A*3001 A01 A03 Aromatic and basic
DDTLYIIRDYWTKW DTLD A*0301, A*1101 A03 Basic
DDTLYIMQDYWTKW DTLD A*3101, A*3301, A*3303, A*7401 A03 Basic
DDTLYIMRDYWTKW DTLD A*6801 A03 Basic
DDTLYIRHYYWTKW DTLY A*6802 A02 Aliphatic
DDTLYIRQDYWTKW DTLD A*6601 A03 Basic
DDTLYLNHDYWTKW DTLD B*2703, B*2705 B27 Hydrophobic and basic
DDTLYLNHHYWTKW DTLH B*2709 B27 Large hydrophobic
DDTLYLSNYYWTKW DTLY B*2707 B27 Large hydrophobic
DDTLYVRHYYWTKW DTLY A*6901 A02 Aliphatic
DGNLYWTNFYWTKW GNLF B*7301 B27 Large hydrophobic
DNIAYLMHYYWTKW NIAY A*2301, A*2402 A24 Large hydrophobic
DNIAYLNHDYWTKW NIAD B*2702 B27 Large hydrophobic
DNTAYLSNYYWTKW NTAY B*0802 B08 Hydrophobic
DNTLYIIEHYWTKW NTLH A*3002-4 A01 Aromatic
DNTLYIIRDYWTKW NTLD A*0101 A01 Aromatic
DNTLYIMRDYWTKW NTLD A*2902 A01 A24 Aromatic and large hydrophobic
DNTLYIRQDYWTKW NTLD A*2601 A01 Aromatic
DNTLYIRQNYWTKW NTLN A*2602 A01 Aromatic
DSIAYIMQDYWTKW SIAD A*3201 A01 Aromatic
DSNLYLRDSYWTKW SNLS B*4601 B62 Large hydrophobic
DSNLYLRNFYWTKW SNLF B*3901-2, B*3909, B*6701 B07 B27 Hydrophobic
DSNLYLSDYYWTKW SNLY B*0702-3 B07 Hydrophobic
DSNLYLSNYYWTKW SNLY B*0705, B*0801, B*4201 B07 Hydrophobic
DSNLYLWNFYWTKW SNLF B*1402 B27 Hydrophobic
DSNLYWTNLYWTKW SNLL B*5401, B*5501-2, B*5601 B07 Small hydrophobic
DSNLYWTNYYWTKW SNLY B*7801 B07 Hydrophobic
DSTLYLNDYYWTKW STLY B*2706 B27 Large hydrophobic
DSTLYLNHDYWTKW STLD B*2704 B27 Large hydrophobic
HDTLYIRQDYWTKW DTLD A*2603 A01 Aromatic
HDTLYLMHYYWTKW DTLY A*0217 A02 Aliphatic
HDTLYLRHYYWTKW DTLY A*0202, A*0205, A*0214 A02 Aliphatic
HDTLYVMHYYWTKW DTLY A*0204 A02 Aliphatic
HDTLYVRHYYWTKW DTLY A*0201, A*0203, A*0206-7 A02 Aliphatic
YDTLYIRNFYWTKW DTLF B*3701 B44 Hydrophobic
YNIAYIRDSYWTKW NIAS B*1513, B*5301, B*5801 B07 B58 B62 Large hydrophobic
YNIAYIVDSYWTKW NIAS B*5701 B58 Large hydrophobic
YNIAYIVNYYWTKW NIAY B*5702 B58 Large hydrophobic
YNIAYLRHDYWTKW NIAD B*1517 B58 Large hydrophobic
YNIAYLRNFYWTKW NIAF B*3801 B27 Large hydrophobic
YNIAYLWDSYWTKW NIAS B*5802 B58 Large hydrophobic
YNIAYWRDSYWTKW NIAS B*1516 B58 Large hydrophobic
YNIAYWTNYYWTKW NIAY B*5101-3, B*5201 B07 B62 Large hydrophobic
YNTAYIRDDYWTKW NTAD B*4402-3 B44 Hydrophobic
YSNLYIRDFYWTKW SNLF B*3503 B07 Hydrophobic
YSNLYIRDSYWTKW SNLS B*1502, B*3501 B07 B62 Hydrophobic
YSNLYLRDSYWTKW SNLS B*1501, B*1503, B*1508, B*1512, B*1518, B*1801 B07 B27 B44 B62 Large hydrophobic
YSNLYLRDYYWTKW SNLY B*1510 B27 Hydrophobic
YSNLYLRNYYWSKL SNLY B*4001 B44 Hydrophobic
YSNLYLRNYYWTKW SNLY B*1509 B27 Hydrophobic
YSNLYLSNYYWSKL SNLY B*4801 B27 Hydrophobic
YSNLYLSNYYWTKW SNLY B*4002 B44 Hydrophobic
YSNLYWRNLYWTKW SNLL B*4501 B44 Small hydrophobic
YSNLYWTNYYWTKW SNLY B*4006 B44 Hydrophobic
  1. 1. Based on data presented in Saper et al, and Madden (see Methods), the MHC residues utilized as constituting the F pocket are: 74, 77, 80, 81, 84, 95, 97, 114, 116, 123, 133, 143, 146, and 147. Key residues are those in positions 77, 80, 81, and 116.
  2. 2. The key residue pockets DTLD, DTLH and DTLY are each associated with two different, although overlapping, specificity descriptions. In each case, one description is associated with HLA B27 alleles, and in the other with HLA A alleles. In assigning key residue matches, matches were assigned on the basis of corresponding locus.