HLA class I supertypes: a revised and updated classification

Sidney, John; Peters, Bjoern; Frahm, Nicole; Brander, Christian; Sette, Alessandro

doi:10.1186/1471-2172-9-1

BMC Immunology

Table 6 F pocket structures of reference panel alleles.

From: HLA class I supertypes: a revised and updated classification

Residues¹	Key residues²	Reference panel allele(s)	Associated supertype(s)	Specificity
DDTLYIIEHYWTKW	DTLH	A*3001	A01 A03	Aromatic and basic
DDTLYIIRDYWTKW	DTLD	A0301, A1101	A03	Basic
DDTLYIMQDYWTKW	DTLD	A3101, A3301, A3303, A7401	A03	Basic
DDTLYIMRDYWTKW	DTLD	A*6801	A03	Basic
DDTLYIRHYYWTKW	DTLY	A*6802	A02	Aliphatic
DDTLYIRQDYWTKW	DTLD	A*6601	A03	Basic
DDTLYLNHDYWTKW	DTLD	B2703, B2705	B27	Hydrophobic and basic
DDTLYLNHHYWTKW	DTLH	B*2709	B27	Large hydrophobic
DDTLYLSNYYWTKW	DTLY	B*2707	B27	Large hydrophobic
DDTLYVRHYYWTKW	DTLY	A*6901	A02	Aliphatic
DGNLYWTNFYWTKW	GNLF	B*7301	B27	Large hydrophobic
DNIAYLMHYYWTKW	NIAY	A2301, A2402	A24	Large hydrophobic
DNIAYLNHDYWTKW	NIAD	B*2702	B27	Large hydrophobic
DNTAYLSNYYWTKW	NTAY	B*0802	B08	Hydrophobic
DNTLYIIEHYWTKW	NTLH	A*3002-4	A01	Aromatic
DNTLYIIRDYWTKW	NTLD	A*0101	A01	Aromatic
DNTLYIMRDYWTKW	NTLD	A*2902	A01 A24	Aromatic and large hydrophobic
DNTLYIRQDYWTKW	NTLD	A*2601	A01	Aromatic
DNTLYIRQNYWTKW	NTLN	A*2602	A01	Aromatic
DSIAYIMQDYWTKW	SIAD	A*3201	A01	Aromatic
DSNLYLRDSYWTKW	SNLS	B*4601	B62	Large hydrophobic
DSNLYLRNFYWTKW	SNLF	B3901-2, B3909, B*6701	B07 B27	Hydrophobic
DSNLYLSDYYWTKW	SNLY	B*0702-3	B07	Hydrophobic
DSNLYLSNYYWTKW	SNLY	B0705, B0801, B*4201	B07	Hydrophobic
DSNLYLWNFYWTKW	SNLF	B*1402	B27	Hydrophobic
DSNLYWTNLYWTKW	SNLL	B5401, B5501-2, B*5601	B07	Small hydrophobic
DSNLYWTNYYWTKW	SNLY	B*7801	B07	Hydrophobic
DSTLYLNDYYWTKW	STLY	B*2706	B27	Large hydrophobic
DSTLYLNHDYWTKW	STLD	B*2704	B27	Large hydrophobic
HDTLYIRQDYWTKW	DTLD	A*2603	A01	Aromatic
HDTLYLMHYYWTKW	DTLY	A*0217	A02	Aliphatic
HDTLYLRHYYWTKW	DTLY	A0202, A0205, A*0214	A02	Aliphatic
HDTLYVMHYYWTKW	DTLY	A*0204	A02	Aliphatic
HDTLYVRHYYWTKW	DTLY	A0201, A0203, A*0206-7	A02	Aliphatic
YDTLYIRNFYWTKW	DTLF	B*3701	B44	Hydrophobic
YNIAYIRDSYWTKW	NIAS	B1513, B5301, B*5801	B07 B58 B62	Large hydrophobic
YNIAYIVDSYWTKW	NIAS	B*5701	B58	Large hydrophobic
YNIAYIVNYYWTKW	NIAY	B*5702	B58	Large hydrophobic
YNIAYLRHDYWTKW	NIAD	B*1517	B58	Large hydrophobic
YNIAYLRNFYWTKW	NIAF	B*3801	B27	Large hydrophobic
YNIAYLWDSYWTKW	NIAS	B*5802	B58	Large hydrophobic
YNIAYWRDSYWTKW	NIAS	B*1516	B58	Large hydrophobic
YNIAYWTNYYWTKW	NIAY	B5101-3, B5201	B07 B62	Large hydrophobic
YNTAYIRDDYWTKW	NTAD	B*4402-3	B44	Hydrophobic
YSNLYIRDFYWTKW	SNLF	B*3503	B07	Hydrophobic
YSNLYIRDSYWTKW	SNLS	B1502, B3501	B07 B62	Hydrophobic
YSNLYLRDSYWTKW	SNLS	B1501, B1503, B1508, B1512, B1518, B1801	B07 B27 B44 B62	Large hydrophobic
YSNLYLRDYYWTKW	SNLY	B*1510	B27	Hydrophobic
YSNLYLRNYYWSKL	SNLY	B*4001	B44	Hydrophobic
YSNLYLRNYYWTKW	SNLY	B*1509	B27	Hydrophobic
YSNLYLSNYYWSKL	SNLY	B*4801	B27	Hydrophobic
YSNLYLSNYYWTKW	SNLY	B*4002	B44	Hydrophobic
YSNLYWRNLYWTKW	SNLL	B*4501	B44	Small hydrophobic
YSNLYWTNYYWTKW	SNLY	B*4006	B44	Hydrophobic

1. Based on data presented in Saper et al, and Madden (see Methods), the MHC residues utilized as constituting the F pocket are: 74, 77, 80, 81, 84, 95, 97, 114, 116, 123, 133, 143, 146, and 147. Key residues are those in positions 77, 80, 81, and 116.
2. The key residue pockets DTLD, DTLH and DTLY are each associated with two different, although overlapping, specificity descriptions. In each case, one description is associated with HLA B27 alleles, and in the other with HLA A alleles. In assigning key residue matches, matches were assigned on the basis of corresponding locus.

Back to article page

ISSN: 1471-2172

Contact us

General enquiries: journalsubmissions@springernature.com