Figure 7
A RAR- α agonist induces and the RAR- α antagonist, R0 41–5254, reduces the expression of CD69 and CD38 on human T cells during activation. PBMC were activated with anti-CD3, mAb in the presence or absence of control ETOH or 10-7 M of ATRA, AM580, or RO41-5254 for 48 h. After activation, the cells were harvested and the cell surface levels of CD69 and CD38 were assessed by flow cytometric analysis as described in the Materials and Methods. The data are representative of all of the donors tested.