The role of Toll-like receptor-4 in pertussis vaccine-induced immunity

BMC Immunology

Table 1 summary of Tlr4 mutation effects (Tlr4^Lps-d vs. wild-type)

	Pre-challenge	Post-challenge		Post-challenge		Post-challenge
		Non-vaccinated		wP-vaccinated		aP-vaccinated
Number of bacteria		↑		↑		↑
Ptx-IgG	=¹	ND³		ND		↓
FHA-IgG	=²	ND		=		=
Prn-IgG	=²	ND		↑		↑
Weight gain		=		=		↓
Lung pathology		=		↓		=
Pro-inflammatory cytokines⁴		↑	↓	↓	↓	=	=
Th1/Th17 cytokines⁴		=	↓	↓	↓	=	=
Th2 cytokines⁴		=	ND	↑	ND	↑	ND

¹Only aP-vaccinated mice showed detectable Ptx-IgG levels. ²Only wP- and aP-vaccinated mice showed detectable FHA-IgG and Prn-IgG levels. ³ND, not detected. ⁴First symbol indicates mRNA expression; second symbol indicates production.

ISSN: 1471-2172