Merge of two top scoring IPA networks derived from the list of 1,345 upregulated LPS-responsive genes. The merged network is depicted in the context of cellular compartments. This upregulated LPS-responsive network contains two nodes in the extracellular compartment having a high degree of connectivity to other network genes: tumor necrosis factor (TNF) and interleukin-1β (IL1B). Gold lines indicate connectivity between the two merged networks. See text for network derivation, and see Additional file 3 for network gene list and Additional file 4 for network legend.