Merge of two top scoring IPA networks derived from the list of 2,623 downregulated LPS-responsive genes. The merged network is depicted in the context of cellular compartments. This downregulated LPS-responsive network contains two nodes in the nuclear compartment having a high degree of connectivity to other network genes: v-myc myelocytomatosis viral oncogene homolog (MYC) and sterol regulatory element binding transcription factor 1 (SREBF1). Gold lines indicate connectivity between the two merged networks. See text for network derivation and see Additional file 6 for network gene list and Additional file 4 for network legend.