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Table 1 Functional annotations associated with the upregulated LPS- and heat shock-responsive genes, respectively.

From: Divergence of canonical danger signals: The genome-level expression patterns of human mononuclear cells subjected to heat shock or lipopolysaccharide

 

LPS

Heat Shock

Pathway (p value)

• Apoptosis signaling (1.5E-10)

• Apoptosis signaling (1.8E-3)

 

• Inflammation mediated by chemokine and cytokine signaling (2.1E-7)

• Angiogenesis (3.2E-2)

 

• Toll receptor signaling (9.6E-6)

 
 

• Integrin signaling (1.4E-2)

 

Biological process (p value)

• Immunity and defense (2.2E-25)

• Protein folding (2.1E-14)

 

• Signal transduction (5.8E-23)

• Protein metabolism and modification (1.7E-10)

 

• Intracellular signaling cascade (3.0E-16)

• Stress response (1.8E-10)

 

• Cell surface receptor mediated signaling (2.7E-10)

• Protein phophorylation (1.7E-6)

 

• Cytokine and chemokine mediated signaling (3.1E-10)

• Immunity and defense (2.0E-5)

Molecular function (p value)

• Signaling molecule (1.4E-10)

• Chaperone (1.2E-16)

 

• Other transcription factor (3.0E-7)

• Hsp 70 family chaperone (1.9E-7)

 

• Chemokine (3.3E-6)

• Protein kinase (2.8E-6)

 

• Cytokine receptor (1.2E-5)

• Transcription factor (2.0E-4)

 

• Select regulatory molecule (8.9E-5)

• Chaperonin (1.2E-3)

  1. Data are based on the PANTHER database using the default parameters in the database and Bonferroni correction for multiple comparisons.