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Figure 4 | BMC Immunology

Figure 4

From: CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis

Figure 4

Changes in the T cell populations expressing CXCR3, IFN-γ, TNF-α, and CXCR3 ligands in IL-10-/- mice after mycobacterial challenge. MLN, PP, and LP lymphocytes were isolated from IL-10-/- mice challenged with cream milk alone (control) or 104 CFU of heat-killed or live M. avium paratuberculosis in cream milk. Changes in the frequency of LP CXCR3+ CD4+ T cells from heat-killed or live Mycobacteria-challenged and control mice (Panel A). Changes in the number (± SEM) of total IFN-γ-, TNF-α-, CXCR3-, CXCL9-, CXCL10- or CXCL11-expressing CD4+ and CD8+ T cell lymphocytes from control mice as well as heat-killed or live Mycobacteria-challenged IL-10-/- mice are shown in Panel B. Asterisks indicate statistically significant differences, i.e., p < 0.01, between control and Mycobacteria-treated groups.

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BMC Immunology

ISSN: 1471-2172

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