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Table 1 Histological evaluation of Mycobacteria-enhanced colitis in IL-10-/- mice

From: CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis

Treatment/Group

Number of Mice

Colitis Disease Score (0 – 12)

Live M. avium paratuberculosis

10

6.12 ± 2.01*

Pasteurized M. avium paratuberculosis

10

4.89 ± 1.41*

Control (vehicle only)

10

1.45 ± 0.79

Untreated wild-type B6

5

0

  1. The severity of colitis was monitored by evaluating the histopathological changes in colons of IL-10-/- mice on B6 background that received 200 μl of cream milk or 104 CFU of live or heat-killed M. avium paratuberculosis in cream milk. Following the sacrifice of mice 14 weeks later, colons were fixed, sectioned at 6 μm and stained with hematoxylin and eosin. The sections were microscopically examined and scored for the severity of colitis. The data presented are the mean ± SEM colitis score. Asterisks indicate statistically significant differences, i.e., p < 0.01 between experimental and the control group.
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BMC Immunology

ISSN: 1471-2172

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