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Table 2 Relationship between baseline variables and levels of total IgE before treatment.

From: Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment

  

Geometric mean total IgE at baseline

Variable

 

Model 1

Model 2

Model 3

Model 4

  

Fold difference (95% CI)

p value

Fold difference (95% CI)

p value

Fold difference (95% CI)

p value

Fold difference (95% CI)

p value

Age (per year)

 

1.01 (0.94–1.10)

0.74

1.01 (0.94–1.09)

0.78

1.02 (0.94–1.10)

0.70

1.05 (0.97–1.12)

0.23

Sex (females relative to males)

 

0.83 (0.64–1.07)

0.15

0.84 (0.65–1.09)

0.20

0.85 (0.66–1.10)

0.22

0.86 (0.68–1.10)

0.24

Body Mass Index (per kg/m2)

 

1.01 (0.94–1.08)

0.81

1.01 (0.95–1.08)

0.73

1.01 (0.95–1.08)

0.68

1.00 (0.94–1.06)

0.98

Socioeconomic level (per unit score)

 

1.10 (0.95–1.27)

0.18

1.09 (0.94–1.26)

0.25

1.11 (0.96–1.28)

0.17

1.06 (0.93–1.21)

0.40

Crowding (per person/sleeping room)

 

0.98 (0.87–1.10)

0.74

0.98 (0.87–1.10)

0.74

0.97 (0.87–1.09)

0.66

1.00 (0.90–1.11)

0.99

Treated group (relative to untreated)

 

0.95 (0.73–1.24)

0.71

0.95 (0.73–1.23)

0.69

0.96 (0.74–1.25)

0.79

0.96 (0.75–1.23)

0.75

Geohelminth prevalence at t = 0 (present versus absent)

         

   Any

 

2.10 (1.60–2.75)

<0.001

    

1.55 (1.19–2.01)

0.001

   A. lumbricoides

   

1.38 (0.99–1.91)

0.06

    

   T. trichiura

   

1.79 (1.31–2.46)

<0.001

    

   Hookworm

   

1.60 (0.99–2.60)

0.06

1.55 (0.95–2.52)

0.08

  

   S. stercoralis

   

0.77 (0.26–2.23)

0.62

0.71 (0.24–2.05)

0.52

  

Geohelminth intensity (epg) at t = 0 (relative to no infection)

         

   A. lumbricoidesa

1–8000

    

1.55 (1.05–2.30)

0.03

  
 

>8000

    

1.33 (0.85–2.08)

0.21

  

   T. trichiurab

1–500

    

1.32 (0.90–1.96)

0.16

  
 

>500

    

2.23 (1.44–3.43)

<0.001

  

Anti-A. lumbricoides antibodies at t = 0

         

(relative to lower tertile) IgGc

         
 

middle tertile

      

1.64 (1.21–2.23)

0.001

 

upper tertile

      

3.51 (2.55–4.82)

<0.001

  1. Statistical significance, after Bonferroni corrections, is inferred by: Model 1 (P < 0.05), Model 2 (P < 0.01), Model 3 (P < 0.008), and Model 4 (P < 0.02). Statistically significant P values are shown in bold for each model. P values for trend: a0.08, b, c<0.001.
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BMC Immunology

ISSN: 1471-2172

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