Figure 2

In vitro ANCA production is induced by CpG-B but not by other B cell stimulants. In addition to CpG-B + IL2, PBMCs from 5 different pairs were also stimulated with either IL2 alone, LPS + IL2, pokeweed mitogen (PWM) + IL2, or inactivated staphylococcus aureus + IL2. A representative set of results is shown from a PR3⁺ ANCA patient (A) and a MPO⁺ ANCA patient (B).