Figure 2
From: Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation
Effect of LTB 4 in solution and released from PLGA microspheres (LTB 4 -loaded MS) on leukocyte rolling flux (A), rolling velocity (B), adhesion (C) and emigration (D) in mice cremaster muscle postcapillary venules. Parameters were measured 4 hours after the intraescrotal administration of saline (negative control), LPS (positive control, 0.05 μg/kg), unloaded and LTB4-loaded MS (1 mg/ml) and LTB4 in solution (200 ng/ml). Results are mean ± SEM (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001, LTB4-loaded MS compared to saline group. # P < 0.05, ## P < 0.01 and &P < 0.05, LTB4-loaded MS compared to unloaded MS and LTB4 solution, respectively.