Figure 2

Profile of gene expression changes in human B cells stimulated with agonists of TLR7, 8 or 9. Purified B cells were stimulated with the indicated IRM or with CpG2006. Gene expression changes were assessed by quantitative real time RT-PCR at 2, 8 or 24 hours after stimulation. The log2 of the maximum fold change over the time course from 2 to 24 hours for 1 representative donor is shown. Hierarchical clustering was performed as described in methods.