Table 2 Gene expression profile of human B cells modulated by TLR7, 8, or 9 agonists from 3 different donors (maximum fold-change through a 2, 8, 24 hour time course).
From: Comparison of human B cell activation by TLR7 and TLR9 agonists
Gene | Alias | 3M-006 | 3M-002 | 852A | 3M-003 | CpG 2006 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D1 | D2 | D3 | D1 | D2 | D3 | D1 | D2 | D3 | D1 | D2 | D3 | D1 | D2 | D3 | ||
FCGR2B | CD32 | -1.2 | -1.7 | -1.2 | -1.3 | -1.9 | -1.3 | -2.6 | -4.7 | -2.1 | -7.4 | -19.1 | -8.4 | -6.7 | -22.8 | -8.6 |
GBP2 | GBP2 | -1.1 | -1.5 | 1.0 | -1.1 | -1.9 | 1.0 | -2.8 | -5.0 | -2.3 | -3.5 | -13.4 | -7.1 | -2.6 | -1.7 | -1.8 |
CD72 | Ly-19 | -1.5 | 1.2 | 1.4 | -1.1 | -1.2 | 1.4 | -3.2 | -3.9 | -1.8 | -5.1 | -9.1 | -4.4 | -3.5 | -5.8 | -2.9 |
GAPDH | GAPDH | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* | 1.0* |
IL12B | IL12p40 | -1.1 | 1.3 | 1.2 | 8.5 | 1.5 | 1.1 | 9.1 | -1.1 | 2.5 | 16.1 | 1.3 | 3.7 | 11.4 | -1.2 | 1.6 |
FCER2 | CD23 | -1.1 | -1.4 | -1.3 | 1.6 | 1.4 | 1.5 | 3.1 | 1.7 | 2.9 | 7.0 | 2.3 | 5.4 | 3.5 | 1.1 | 3.7 |
CCL20 | MIP3a | -1.2 | -1.2 | 1.2 | 52.3 | 6.7 | 1.3 | 2.9 | -1.6 | 1.0 | 28.6 | 2.6 | 1.4 | -2.9 | -2.1 | 1.0 |
IL-1B | IL1F2 | -1.7 | -1.6 | -1.8 | 31.1 | 8.2 | 29.1 | 2.6 | 1.7 | 2.8 | 28.8 | 5.4 | 9.8 | 3.9 | -1.7 | 3.2 |
COX-2 | PTGS2 | -1.2 | -2.8 | 1.3 | 21.7 | 5.0 | 2.0 | -2.7 | 2.0 | 2.7 | 16.8 | 3.6 | 5.6 | 4.9 | 8.3 | 2.2 |
CD86 | B7-2 | -1.2 | -1.2 | 1.2 | 1.2 | 1.3 | 1.3 | 2.1 | 2.3 | 2.3 | 2.8 | 5.0 | 4.1 | 1.6 | 3.8 | 1.9 |
CD40 | TNFRSF5 | 1.1 | 1.1 | 1.1 | 1.6 | 1.6 | 1.6 | 3.7 | 2.6 | 3.1 | 6.1 | 4.7 | 6.0 | 4.7 | 4.0 | 3.0 |
FOS | c-fos | 1.1 | 1.4 | 1.6 | -1.3 | 1.6 | 1.8 | -2.0 | 2.8 | 2.7 | -3.7 | 4.7 | 6.1 | -2.7 | -2.0 | -1.6 |
GOS-2 | RP1 | -1.4 | -1.4 | 2.0 | 2.3 | 2.0 | 2.6 | 3.1 | 2.7 | 4.4 | 6.3 | 4.5 | 10.0 | 5.3 | 5.1 | 7.5 |
NFKB1A | IKBA | 1.1 | 1.5 | 1.4 | 1.9 | 1.7 | 2.2 | 3.8 | 3.8 | 4.2 | 4.8 | 4.2 | 6.6 | 4.0 | 4.2 | 5.4 |
TR3 | TNFRSF25 | 1.3 | 1.8 | 1.6 | 1.2 | 1.9 | 2.1 | 1.5 | 4.0 | 3.5 | -2.7 | 3.2 | 5.6 | 2.0 | 3.6 | -1.5 |
CD58 | LFA3 | 1.1 | 1.2 | 1.2 | 1.3 | 1.5 | 1.6 | 2.0 | 3.8 | 3.2 | 3.3 | 4.8 | 5.0 | 3.2 | 5.2 | 5.5 |
IL21r | NILR | 1.3 | 1.4 | 1.3 | 1.7 | 2.2 | 2.2 | 3.5 | 4.7 | 5.4 | 4.9 | 5.7 | 6.7 | 4.0 | 5.1 | 6.3 |
MYC | c-myc | -1.2 | 1.4 | 1.4 | 1.6 | 1.7 | 1.9 | 2.1 | 3.7 | 3.2 | 3.5 | 7.0 | 10.7 | 3.6 | 12.3 | 8.1 |
CD80 | B7-1 | 1.2 | 1.4 | 1.2 | 2.0 | 1.9 | 1.8 | 3.9 | 4.8 | 3.8 | 7.3 | 8.6 | 8.1 | 6.1 | 6.9 | 6.4 |
TNFa | TNFSF2 | -1.2 | 1.4 | 1.2 | 3.1 | 2.2 | 1.7 | 9.5 | 6.9 | 7.7 | 14.9 | 10.3 | 16.2 | 13.8 | 11.8 | 7.0 |
IL1a | IL1F1 | -1.7 | 1.5 | 1.2 | 2.5 | 4.5 | 1.5 | 4.0 | 4.3 | 2.8 | 5.7 | 11.4 | 6.8 | 4.6 | 11.7 | 2.9 |
CCL4 | MIP1b | 1.4 | 1.0 | 1.2 | 3.3 | 2.3 | 3.0 | 6.1 | 7.1 | 5.7 | 10.8 | 10.9 | 32.6 | 22.3 | 38.6 | 37.4 |
CCL3 | MIP1a | 1.2 | 1.2 | 1.5 | 4.5 | 2.4 | 2.9 | 11.4 | 10.0 | 10.1 | 18.9 | 15.6 | 45.6 | 39.3 | 45.6 | 62.3 |
BFCL2L1 | Bcl-xl | -1.3 | -1.1 | 1.3 | 1.9 | 1.8 | 2.1 | 4.5 | 8.3 | 6.4 | 6.1 | 21.7 | 15.1 | 5.1 | 12.8 | 9.2 |
DSP2 | PAC1 | 1.3 | 1.5 | 1.2 | 1.2 | 2.8 | 2.0 | 2.3 | 10.8 | 4.6 | 4.0 | 16.1 | 18.3 | 3.7 | 13.5 | 5.0 |
LTA | TNFSF1 | 1.0 | 1.3 | 1.3 | 6.1 | 2.5 | 2.5 | 63.0 | 18.8 | 24.3 | 85.8 | 18.5 | 32.0 | 55.5 | 22.1 | 24.9 |
TCFL5 | E2BP1 | -1.2 | 1.3 | 1.2 | 1.6 | 3.1 | 2.0 | 9.7 | 17.7 | 9.4 | 22.6 | 25.2 | 24.9 | 16.3 | 23.5 | 18.7 |
IL-6 | IFNB2 | 1.9 | 2.4 | 1.0 | 7.0 | 4.7 | 6.1 | 24.9 | 25.6 | 40.4 | 70.8 | 51.3 | 71.9 | 58.9 | 59.4 | 53.2 |