Comparison of human B cell activation by TLR7 and TLR9 agonists

BMC Immunology

Table 3 Interferon and interferon-inducible genes in human B cells were minimally and inconsistently modulated by TLR7, 8, or 9 agonists from 3 different donors (maximum fold-change through a 2, 8, 24 hour time course).

Gene	Alias	3M-006			3M-002			852A			3M-003			CpG 2006
		D1	D2	D3	D1	D2	D3	D1	D2	D3	D1	D2	D3	D1	D2	D3
GAPDH	GAPDH	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*	1.0*
IFNa-2	IFNa-2	2.6	1.7	1.5	3.5	1.8	1.4	3.0	-1.3	1.2	-2.2	-1.5	-1.2	4.0	-1.7	-1.2
ISG15	ISG15	1.6	1.3	1.2	1.9	1.1	1.5	1.2	1.5	1.8	3.0	-2.7	2.3	-1.5	-2.2	-1.5
MX1	MX1	1.3	-1.2	1.3	1.7	-1.5	1.1	1.5	-2.3	-1.6	6.8	-3.3	-4.2	-3.9	-3.4	-4.3
TLR7	TLR7	1.5	-1.2	1.6	1.2	-1.3	1.3	-2.8	-2.7	-1.6	-2.9	-2.1	-4.3	-3.5	-6.7	-4.5
TLR9	TLR9	-1.3	-1.2	-1.1	1.0	-1.3	-1.1	-1.9	-1.5	-1.4	-3.1	-3.9	-2.3	-3.2	-3.0	-1.7

The data represented in Table 3 and Table 2 are from the same experiment, but were separated into 2 different tables for illustration purposes.
(a) normal text = subjectively assigned nominal to low fold change (-3.4 to 3.4).
(b) bold text, negative = subjectively assigned moderate fold suppression (-23.0 to -3.5).
(c) bold text, positive = subjectively assigned moderate to high fold increase (3.5 to 86.0).
(d) text with * = GAPDH, house keeping gene as a reference.

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