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Table 1 Adjuvant effect of test compounds based on the IgG1 levels.

From: Structure-activity relationship of immunostimulatory effects of phthalates

Compound Adjuvant factora (dose of test compound)
  1 booster 2 boosters
1: Di-n-butyl phthalate NDb 24 (10 μg)c
2: Benzyl butyl phthalate 1d 1d
3: Di-(2-ethylhexyl) phthalate (DEHP)   13 (10 μg)
  33 (100 μg) 61 (100 μg)
4: Butyldodecyl phthalate (BDP)   20 (10 μg)
  14 (100 μg) 68 (100 μg)
5: Di-n-octyl phthalate ND 61 (100 μg)c
6: Bis-(2-ethylhexyl) terephthalate (DOTP) 1 4 (100 μg)
7: Diisononyl phthalate ND 42 (both 10 and 100 μg)c
8: Diisodecyl phthalate ND 1c
9: Trioctyl trimellitate (TOTM) 1 1
10: Methylpalmitate (MP) 1 1
  1. a) Adjuvant factor taken as the ratio between the IgG1 level in the test group and the OVA control group.
  2. b) ND: Not defined, as the median IgG1 value in the OVA control group was zero.
  3. c) Data are calculated from reference 5. Cf. 'Material and Method' for details.
  4. d) Data are calculated from reference 11. Cf. 'Material and Method' for details.