TY - JOUR AU - Gordon, H. A. PY - 1959 DA - 1959// TI - Morphological and physiological characterization of germfree life JO - Ann N Y Acad Sci VL - 78 UR - https://doi.org/10.1111/j.1749-6632.1959.tb53104.x DO - 10.1111/j.1749-6632.1959.tb53104.x ID - Gordon1959 ER - TY - JOUR AU - Hudson, J. A. AU - Luckey, T. D. PY - 1964 DA - 1964// TI - Bacteria Induced Morphologic Changes JO - Proc Soc Exp Biol Med VL - 116 UR - https://doi.org/10.3181/00379727-116-29324 DO - 10.3181/00379727-116-29324 ID - Hudson1964 ER - TY - JOUR AU - Savage, D. C. PY - 1977 DA - 1977// TI - Microbial ecology of the gastrointestinal tract JO - Annu Rev Microbiol VL - 31 UR - https://doi.org/10.1146/annurev.mi.31.100177.000543 DO - 10.1146/annurev.mi.31.100177.000543 ID - Savage1977 ER - TY - JOUR AU - Wostmann, B. S. PY - 1981 DA - 1981// TI - The germfree animal in nutritional studies JO - Annu Rev Nutr VL - 1 UR - https://doi.org/10.1146/annurev.nu.01.070181.001353 DO - 10.1146/annurev.nu.01.070181.001353 ID - Wostmann1981 ER - TY - JOUR AU - Hooper, L. V. AU - Gordon, J. I. PY - 2001 DA - 2001// TI - Commensal host-bacterial relationships in the gut JO - Science VL - 292 UR - https://doi.org/10.1126/science.1058709 DO - 10.1126/science.1058709 ID - Hooper2001 ER - TY - JOUR AU - Wostmann, B. S. AU - Pleasants, J. R. AU - Bealmear, P. AU - Kincade, P. W. PY - 1970 DA - 1970// TI - Serum proteins and lymphoid tissues in germ-free mice fed a chemically defined, water soluble, low molecular weight diet JO - Immunology VL - 19 ID - Wostmann1970 ER - TY - JOUR AU - Tlaskalova, H. AU - Kamarytova, V. AU - Mandel, L. AU - Prokesova, L. AU - Kruml, J. AU - Lanc, A. AU - Miler, I. PY - 1970 DA - 1970// TI - The immune response of germ-free piglets after peroral monocontamination with living Escherichia coli strain 086. I. The fate of antigen, dynamics and site of antibody formation, nature of antibodies and formation of heterohaemagglutinins JO - Folia Biol (Praha) VL - 16 ID - Tlaskalova1970 ER - TY - JOUR AU - Crabbe, P. A. AU - Nash, D. R. AU - Bazin, H. AU - Eyssen, H. AU - Heremans, J. F. PY - 1970 DA - 1970// TI - Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice JO - Lab Invest VL - 22 ID - Crabbe1970 ER - TY - JOUR AU - Moreau, M. C. AU - Ducluzeau, R. AU - Guy-Grand, D. AU - Muller, M. C. PY - 1978 DA - 1978// TI - Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin JO - Infect Immun VL - 21 ID - Moreau1978 ER - TY - JOUR AU - Tlaskalova-Hogenova, H. AU - Sterzl, J. AU - Stepankova, R. AU - Dlabac, V. AU - Veticka, V. AU - Rossmann, P. AU - Mandel, L. AU - Rejnek, J. PY - 1983 DA - 1983// TI - Development of immunological capacity under germfree and conventional conditions JO - Ann N Y Acad Sci VL - 409 UR - https://doi.org/10.1111/j.1749-6632.1983.tb26862.x DO - 10.1111/j.1749-6632.1983.tb26862.x ID - Tlaskalova-Hogenova1983 ER - TY - JOUR AU - Bos, N. A. AU - Kimura, H. AU - Meeuwsen, C. G. AU - De Visser, H. AU - Hazenberg, M. P. AU - Wostmann, B. S. AU - Pleasants, J. R. AU - Benner, R. AU - Marcus, D. M. PY - 1989 DA - 1989// TI - Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet JO - Eur J Immunol VL - 19 UR - https://doi.org/10.1002/eji.1830191223 DO - 10.1002/eji.1830191223 ID - Bos1989 ER - TY - JOUR AU - Umesaki, Y. AU - Setoyama, H. AU - Matsumoto, S. AU - Okada, Y. PY - 1993 DA - 1993// TI - Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus JO - Immunology VL - 79 ID - Umesaki1993 ER - TY - JOUR AU - Imaoka, A. AU - Matsumoto, S. AU - Setoyama, H. AU - Okada, Y. AU - Umesaki, Y. PY - 1996 DA - 1996// TI - Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ-free mice JO - Eur J Immunol VL - 26 UR - https://doi.org/10.1002/eji.1830260434 DO - 10.1002/eji.1830260434 ID - Imaoka1996 ER - TY - JOUR AU - Cebra, J. J. PY - 1999 DA - 1999// TI - Influences of microbiota on intestinal immune system development JO - Am J Clin Nutr VL - 69 ID - Cebra1999 ER - TY - JOUR AU - Hooper, L. V. AU - Stappenbeck, T. S. AU - Hong, C. V. AU - Gordon, J. I. PY - 2003 DA - 2003// TI - Angiogenins: a new class of microbicidal proteins involved in innate immunity JO - Nat Immunol VL - 4 UR - https://doi.org/10.1038/ni888 DO - 10.1038/ni888 ID - Hooper2003 ER - TY - JOUR AU - Helgeland, L. AU - Dissen, E. AU - Dai, K. Z. AU - Midtvedt, T. AU - Brandtzaeg, P. AU - Vaage, J. T. PY - 2004 DA - 2004// TI - Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut JO - Eur J Immunol VL - 34 UR - https://doi.org/10.1002/eji.200425122 DO - 10.1002/eji.200425122 ID - Helgeland2004 ER - TY - JOUR AU - Hooper, L. V. PY - 2004 DA - 2004// TI - Bacterial contributions to mammalian gut development JO - Trends Microbiol VL - 12 UR - https://doi.org/10.1016/j.tim.2004.01.001 DO - 10.1016/j.tim.2004.01.001 ID - Hooper2004 ER - TY - JOUR AU - Tlaskalova-Hogenova, H. AU - Stepankova, R. AU - Hudcovic, T. AU - Tuckova, L. AU - Cukrowska, B. AU - Lodinova-Zadnikova, R. AU - Kozakova, H. AU - Rossmann, P. AU - Bartova, J. AU - Sokol, D. PY - 2004 DA - 2004// TI - Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases JO - Immunol Lett VL - 93 UR - https://doi.org/10.1016/j.imlet.2004.02.005 DO - 10.1016/j.imlet.2004.02.005 ID - Tlaskalova-Hogenova2004 ER - TY - JOUR AU - Verdu, E. F. AU - Collins, S. M. PY - 2004 DA - 2004// TI - Microbial-gut interactions in health and disease. Irritable bowel syndrome JO - Best Pract Res Clin Gastroenterol VL - 18 UR - https://doi.org/10.1016/j.bpg.2003.11.003 DO - 10.1016/j.bpg.2003.11.003 ID - Verdu2004 ER - TY - JOUR AU - Mazmanian, S. K. AU - Liu, C. H. AU - Tzianabos, A. O. AU - Kasper, D. L. PY - 2005 DA - 2005// TI - An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system JO - Cell VL - 122 UR - https://doi.org/10.1016/j.cell.2005.05.007 DO - 10.1016/j.cell.2005.05.007 ID - Mazmanian2005 ER - TY - JOUR AU - Tlaskalova-Hogenova, H. AU - Tuckova, L. AU - Mestecky, J. AU - Kolinska, J. AU - Rossmann, P. AU - Stepankova, R. AU - Kozakova, H. AU - Hudcovic, T. AU - Hrncir, T. AU - Frolova, L. PY - 2005 DA - 2005// TI - Interaction of mucosal microbiota with the innate immune system JO - Scand J Immunol VL - 62 UR - https://doi.org/10.1111/j.1365-3083.2005.01618.x DO - 10.1111/j.1365-3083.2005.01618.x ID - Tlaskalova-Hogenova2005 ER - TY - JOUR AU - Williams, A. M. AU - Probert, C. S. AU - Stepankova, R. AU - Tlaskalova-Hogenova, H. AU - Phillips, A. AU - Bland, P. W. PY - 2006 DA - 2006// TI - Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse JO - Immunology VL - 119 UR - https://doi.org/10.1111/j.1365-2567.2006.02458.x DO - 10.1111/j.1365-2567.2006.02458.x ID - Williams2006 ER - TY - JOUR AU - Probert, C. S. AU - Williams, A. M. AU - Stepankova, R. AU - Tlaskalova-Hogenova, H. AU - Phillips, A. AU - Bland, P. W. PY - 2007 DA - 2007// TI - The effect of weaning on the clonality of alpha beta T-cell receptor T cells in the intestine of GF and SPF mice JO - Dev Comp Immunol VL - 31 UR - https://doi.org/10.1016/j.dci.2006.08.008 DO - 10.1016/j.dci.2006.08.008 ID - Probert2007 ER - TY - JOUR AU - Wostmann, B. S. AU - Pleasants, J. R. PY - 1991 DA - 1991// TI - The germ-free animal fed chemically defined diet: a unique tool JO - Proc Soc Exp Biol Med VL - 198 UR - https://doi.org/10.3181/00379727-198-43286D DO - 10.3181/00379727-198-43286D ID - Wostmann1991 ER - TY - JOUR AU - Bowman, L. M. AU - Holt, P. G. PY - 2001 DA - 2001// TI - Selective enhancement of systemic Th1 immunity in immunologically immature rats with an orally administered bacterial extract JO - Infect Immun VL - 69 UR - https://doi.org/10.1128/IAI.69.6.3719-3727.2001 DO - 10.1128/IAI.69.6.3719-3727.2001 ID - Bowman2001 ER - TY - JOUR AU - Neurath, M. F. AU - Finotto, S. AU - Glimcher, L. H. PY - 2002 DA - 2002// TI - The role of Th1/Th2 polarization in mucosal immunity JO - Nat Med VL - 8 UR - https://doi.org/10.1038/nm0602-567 DO - 10.1038/nm0602-567 ID - Neurath2002 ER - TY - JOUR AU - Rook, G. A. AU - Brunet, L. R. PY - 2002 DA - 2002// TI - Give us this day our daily germs JO - Biologist (London) VL - 49 ID - Rook2002 ER - TY - JOUR AU - Sheikh, A. AU - Strachan, D. P. PY - 2004 DA - 2004// TI - The hygiene theory: fact or fiction? JO - Curr Opin Otolaryngol Head Neck Surg VL - 12 UR - https://doi.org/10.1097/01.moo.0000122311.13359.30 DO - 10.1097/01.moo.0000122311.13359.30 ID - Sheikh2004 ER - TY - JOUR AU - Annacker, O. AU - Burlen-Defranoux, O. AU - Pimenta-Araujo, R. AU - Cumano, A. AU - Bandeira, A. PY - 2000 DA - 2000// TI - Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment JO - J Immunol VL - 164 UR - https://doi.org/10.4049/jimmunol.164.7.3573 DO - 10.4049/jimmunol.164.7.3573 ID - Annacker2000 ER - TY - JOUR AU - Gad, M. AU - Pedersen, A. E. AU - Kristensen, N. N. AU - Claesson, M. H. PY - 2004 DA - 2004// TI - Demonstration of strong enterobacterial reactivity of CD4+CD25- T cells from conventional and germ-free mice which is counter-regulated by CD4+CD25+ T cells JO - Eur J Immunol VL - 34 UR - https://doi.org/10.1002/eji.200324394 DO - 10.1002/eji.200324394 ID - Gad2004 ER - TY - JOUR AU - Strauch, U. G. AU - Obermeier, F. AU - Grunwald, N. AU - Gurster, S. AU - Dunger, N. AU - Schultz, M. AU - Griese, D. P. AU - Mahler, M. AU - Scholmerich, J. AU - Rath, H. C. PY - 2005 DA - 2005// TI - Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis JO - Gut VL - 54 UR - https://doi.org/10.1136/gut.2004.059451 DO - 10.1136/gut.2004.059451 ID - Strauch2005 ER - TY - JOUR AU - Ostman, S. AU - Rask, C. AU - Wold, A. E. AU - Hultkrantz, S. AU - Telemo, E. PY - 2006 DA - 2006// TI - Impaired regulatory T cell function in germ-free mice JO - Eur J Immunol VL - 36 UR - https://doi.org/10.1002/eji.200535244 DO - 10.1002/eji.200535244 ID - Ostman2006 ER - TY - JOUR AU - Min, B. AU - Thornton, A. AU - Caucheteux, S. M. AU - Younes, S. A. AU - Oh, K. AU - Hu-Li, J. AU - Paul, W. E. PY - 2007 DA - 2007// TI - Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis JO - Eur J Immunol VL - 37 UR - https://doi.org/10.1002/eji.200737236 DO - 10.1002/eji.200737236 ID - Min2007 ER - TY - JOUR AU - Hori, S. AU - Nomura, T. AU - Sakaguchi, S. PY - 2003 DA - 2003// TI - Control of regulatory T cell development by the transcription factor Foxp3 JO - Science VL - 299 UR - https://doi.org/10.1126/science.1079490 DO - 10.1126/science.1079490 ID - Hori2003 ER - TY - JOUR AU - Fontenot, J. D. AU - Gavin, M. A. AU - Rudensky, A. Y. PY - 2003 DA - 2003// TI - Foxp3 programs the development and function of CD4+CD25+ regulatory T cells JO - Nat Immunol VL - 4 UR - https://doi.org/10.1038/ni904 DO - 10.1038/ni904 ID - Fontenot2003 ER - TY - JOUR AU - Khattri, R. AU - Cox, T. AU - Yasayko, S. A. AU - Ramsdell, F. PY - 2003 DA - 2003// TI - An essential role for Scurfin in CD4+CD25+ T regulatory cells JO - Nat Immunol VL - 4 UR - https://doi.org/10.1038/ni909 DO - 10.1038/ni909 ID - Khattri2003 ER - TY - JOUR AU - Singh, B. AU - Read, S. AU - Asseman, C. AU - Malmstrom, V. AU - Mottet, C. AU - Stephens, L. A. AU - Stepankova, R. AU - Tlaskalova, H. AU - Powrie, F. PY - 2001 DA - 2001// TI - Control of intestinal inflammation by regulatory T cells JO - Immunol Rev VL - 182 UR - https://doi.org/10.1034/j.1600-065X.2001.1820115.x DO - 10.1034/j.1600-065X.2001.1820115.x ID - Singh2001 ER - TY - JOUR AU - Bennett, C. L. AU - Christie, J. AU - Ramsdell, F. AU - Brunkow, M. E. AU - Ferguson, P. J. AU - Whitesell, L. AU - Kelly, T. E. AU - Saulsbury, F. T. AU - Chance, P. F. AU - Ochs, H. D. PY - 2001 DA - 2001// TI - The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 JO - Nat Genet VL - 27 UR - https://doi.org/10.1038/83713 DO - 10.1038/83713 ID - Bennett2001 ER - TY - JOUR AU - Brunkow, M. E. AU - Jeffery, E. W. AU - Hjerrild, K. A. AU - Paeper, B. AU - Clark, L. B. AU - Yasayko, S. A. AU - Wilkinson, J. E. AU - Galas, D. AU - Ziegler, S. F. AU - Ramsdell, F. PY - 2001 DA - 2001// TI - Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse JO - Nat Genet VL - 27 UR - https://doi.org/10.1038/83784 DO - 10.1038/83784 ID - Brunkow2001 ER - TY - JOUR AU - Fontenot, J. D. AU - Rasmussen, J. P. AU - Williams, L. M. AU - Dooley, J. L. AU - Farr, A. G. AU - Rudensky, A. Y. PY - 2005 DA - 2005// TI - Regulatory T cell lineage specification by the forkhead transcription factor foxp3 JO - Immunity VL - 22 UR - https://doi.org/10.1016/j.immuni.2005.01.016 DO - 10.1016/j.immuni.2005.01.016 ID - Fontenot2005 ER - TY - JOUR AU - Jiang, Q. AU - Su, H. AU - Knudsen, G. AU - Helms, W. AU - Su, L. PY - 2006 DA - 2006// TI - Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP JO - BMC Immunol VL - 7 UR - https://doi.org/10.1186/1471-2172-7-6 DO - 10.1186/1471-2172-7-6 ID - Jiang2006 ER - TY - JOUR AU - Jiang, Q. AU - Coffield, V. M. AU - Kondo, M. AU - Su, L. PY - 2007 DA - 2007// TI - TSLP is involved in expansion of early thymocyte progenitors JO - BMC Immunol VL - 8 UR - https://doi.org/10.1186/1471-2172-8-11 DO - 10.1186/1471-2172-8-11 ID - Jiang2007 ER - TY - JOUR AU - Iwasaki, A. AU - Medzhitov, R. PY - 2004 DA - 2004// TI - Toll-like receptor control of the adaptive immune responses JO - Nat Immunol VL - 5 UR - https://doi.org/10.1038/ni1112 DO - 10.1038/ni1112 ID - Iwasaki2004 ER - TY - JOUR AU - Figdor, C. G. AU - van Kooyk, Y. AU - Adema, G. J. PY - 2002 DA - 2002// TI - C-type lectin receptors on dendritic cells and Langerhans cells JO - Nat Rev Immunol VL - 2 UR - https://doi.org/10.1038/nri723 DO - 10.1038/nri723 ID - Figdor2002 ER - TY - JOUR AU - Inohara AU - Chamaillard AU - McDonald, C. AU - Nunez, G. PY - 2005 DA - 2005// TI - NOD-LRR proteins: role in host-microbial interactions and inflammatory disease JO - Annu Rev Biochem VL - 74 UR - https://doi.org/10.1146/annurev.biochem.74.082803.133347 DO - 10.1146/annurev.biochem.74.082803.133347 ID - Inohara2005 ER - TY - JOUR AU - Hashimoto, K. AU - Handa, H. AU - Umehara, K. AU - Sasaki, S. PY - 1978 DA - 1978// TI - Germfree mice reared on an "antigen-free" diet JO - Lab Anim Sci VL - 28 ID - Hashimoto1978 ER - TY - JOUR AU - Hooijkaas, H. AU - Benner, R. AU - Pleasants, J. R. AU - Wostmann, B. S. PY - 1984 DA - 1984// TI - Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered "antigen-free" diet JO - Eur J Immunol VL - 14 UR - https://doi.org/10.1002/eji.1830141212 DO - 10.1002/eji.1830141212 ID - Hooijkaas1984 ER - TY - JOUR AU - Pereira, P. AU - Forni, L. AU - Larsson, E. L. AU - Cooper, M. AU - Heusser, C. AU - Coutinho, A. PY - 1986 DA - 1986// TI - Autonomous activation of B and T cells in antigen-free mice JO - Eur J Immunol VL - 16 UR - https://doi.org/10.1002/eji.1830160616 DO - 10.1002/eji.1830160616 ID - Pereira1986 ER - TY - JOUR AU - Dobber, R. AU - Hertogh-Huijbregts, A. AU - Rozing, J. AU - Bottomly, K. AU - Nagelkerken, L. PY - 1992 DA - 1992// TI - The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery JO - Dev Immunol VL - 2 UR - https://doi.org/10.1155/1992/57057 DO - 10.1155/1992/57057 ID - Dobber1992 ER - TY - JOUR AU - Bjorksten, B. AU - Naaber, P. AU - Sepp, E. AU - Mikelsaar, M. PY - 1999 DA - 1999// TI - The intestinal microflora in allergic Estonian and Swedish 2-year-old children JO - Clin Exp Allergy VL - 29 UR - https://doi.org/10.1046/j.1365-2222.1999.00560.x DO - 10.1046/j.1365-2222.1999.00560.x ID - Bjorksten1999 ER - TY - JOUR AU - Bjorksten, B. AU - Sepp, E. AU - Julge, K. AU - Voor, T. AU - Mikelsaar, M. PY - 2001 DA - 2001// TI - Allergy development and the intestinal microflora during the first year of life JO - J Allergy Clin Immunol VL - 108 UR - https://doi.org/10.1067/mai.2001.118130 DO - 10.1067/mai.2001.118130 ID - Bjorksten2001 ER - TY - JOUR AU - Guarner, F. AU - Bourdet-Sicard, R. AU - Brandtzaeg, P. AU - Gill, H. S. AU - McGuirk, P. AU - van Eden, W. AU - Versalovic, J. AU - Weinstock, J. V. AU - Rook, G. A. PY - 2006 DA - 2006// TI - Mechanisms of disease: the hygiene hypothesis revisited JO - Nat Clin Pract Gastroenterol Hepatol VL - 3 UR - https://doi.org/10.1038/ncpgasthep0471 DO - 10.1038/ncpgasthep0471 ID - Guarner2006 ER - TY - JOUR AU - Schaffler, A. AU - Scholmerich, J. AU - Salzberger, B. PY - 2007 DA - 2007// TI - Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs JO - Trends Immunol VL - 28 UR - https://doi.org/10.1016/j.it.2007.07.003 DO - 10.1016/j.it.2007.07.003 ID - Schaffler2007 ER - TY - JOUR AU - Taylor, P. R. AU - Tsoni, S. V. AU - Willment, J. A. AU - Dennehy, K. M. AU - Rosas, M. AU - Findon, H. AU - Haynes, K. AU - Steele, C. AU - Botto, M. AU - Gordon, S. PY - 2007 DA - 2007// TI - Dectin-1 is required for beta-glucan recognition and control of fungal infection JO - Nat Immunol VL - 8 UR - https://doi.org/10.1038/ni1408 DO - 10.1038/ni1408 ID - Taylor2007 ER - TY - JOUR AU - Tuckova, L. AU - Novotna, J. AU - Novak, P. AU - Flegelova, Z. AU - Kveton, T. AU - Jelinkova, L. AU - Zidek, Z. AU - Man, P. AU - Tlaskalova-Hogenova, H. PY - 2002 DA - 2002// TI - Activation of macrophages by gliadin fragments: isolation and characterization of active peptide JO - J Leukoc Biol VL - 71 ID - Tuckova2002 ER - TY - JOUR AU - Macpherson, A. J. AU - Smith, K. PY - 2006 DA - 2006// TI - Mesenteric lymph nodes at the center of immune anatomy JO - J Exp Med VL - 203 UR - https://doi.org/10.1084/jem.20060227 DO - 10.1084/jem.20060227 ID - Macpherson2006 ER -