Figure 2
From: Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection
Systemic cytokine profile during experimental S. Typhimurium infection in Asc−/−and Nlrp3−/−mice (typhoid model). Cytokines were measured in plasma of WT (white), Asc−/− (grey) and Nlrp3−/− (black) mice 5 days after infection with S. Typhimurium (106). Levels of TNF-α (tumor necrosis factor-alpha; A), IFN-γ (interferon-gamma; B), MCP-1 (monocyte chemo attractive protein-1; C), IL-6 (interleukin-6; D), IL-10 (E), IL-12p70 (F) are shown. Data are presented as means ± SEM of 6–12 mice per genotype, with limit of detection (dashed lines). Statistical significance was determined using the unpaired Mann- Whitney U test. *, p < 0.05.