Figure 4
From: Limited role for ASC and NLRP3 during in vivo Salmonella Typhimurium infection
In a typhoid mouse model markers of hepatocellular injury are equally enhanced in all genotypes. Aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH), measured in blood plasma in WT (white), Asc−/− (grey) (A-C) and Nlrp3−/− (black) (D-F) mice after oral infection with S. Typhimurium (106; typhoid model). UI, uninfected controls (striped). In all charts the mean and SEM is shown. Graphs depict 8–12 mice per genotype and per time-point. NB. Experiments at day 5 were performed with all three genotypes simultaneously; for reasons of clarity WT results are used in both Asc- and Nlrp3 graphs.