Table 1 Inclusion criteria for evaluation of primary immunodeficiency disease *

1)

Six or more new ear infections within 1 year; otitis with complications such as chronic perforation or mastoiditis

2)

Two or more serious sinus infections within 1 year

3)

Infections that do not heal as expected during antibiotic treatment

4)

Two or more pneumonias within 1 year

5)

Failure of an infant to gain weight or grow normally

6)

Recurrent, deep skin infections or organ abscesses

7)

Chronic severe oral or cutaneous candidiasis

8)

Infections caused by unusual microbial agents and/or with unusual localization

9)

Two or more invasive infections such as osteomyelitis, meningitis or sepsis

10)

A family history of PID

11)

Recurrent fever or fever lasting more than 6 weeks

12)

Excessive number of upper respiratory tract infections (more than 8 per year)