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Figure 3 | BMC Immunology

Figure 3

From: Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells

Figure 3

Association of memory T cell GrzB secretion with activation and degranulation markers. (A-D) Memory T cell flow cytometry dotplots and mean ± sem (n = 16-17) total surface CD69 expression or CD69+/GrzB+ coexpression (gated on total memory CD4 or memory CD8 T cells), or CD69 expression gated on GrzB+ memory CD4 or memory CD8 T cells. (E-H) Flow cytometry dotplots and mean ± sem (n = 6) total surface CD107a expression or CD107a+/GrzB+ coexpression (gated on total memory CD4 or memory CD8 T cells), or CD107a expression gated on GrzB+ memory CD4 or memory CD8 T cells. (I) GrzB ELISA of memory T cells conducted in parallel with CD107a experiments. (J-K) Spearman correlations between CD107a and intracellular (flow cytometry) or extracellular (ELISA) GrzB of memory T cells (n = 8-12).

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BMC Immunology

ISSN: 1471-2172

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