Figure 5

MSP and RON expression in kidney of control and allografted rats on day 7. Groups are defined as in Figure 8. Panel a: MSP expression in representative renal section of normal kidney, note the strong cytoplasmic pattern of staining, panel b: MSP expression in representative renal section of untreated allograft, note the almost complete absence of MSP expression, panel c: MSP expression in representative renal section of MSC treated allograft, note the luminal pattern of MSP staining (Magnification X200). Panel d: RON expression in representative renal sections of normal kidney, panel e: RON expression in representative renal sections of untreated allograft, note the presence of RON positive inflammatory cells and the significant reduction of RON tubular staining, panel f: RON expression in representative renal sections of MSC treated allograft, note the reappearance of RON tubular staining and absence of RON positive inflammatory cells (Magnification X200). Panel g: Bars represent the medians of MSP positive tubules number/HPF in all groups of rats; Boxes represent 25-75% percentile of MSP positive tubules, whiskers: min to max) i: §p < 0.005 vs B; *p < 0.05 vs C, ^§ p < 0.01 vs A. Panel h: Bars represent the medians of RON positive tubule number/HPF in all groups, boxes represent the 25-75% percentile, whiskers: min to max. *p < 0.01 vs C, §p < 0.005 vs B and C.