Figure 3
From: C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media
Regulation of JNK signaling genes during OM. ME expression of genes related to the JNK signaling pathway in WT mice during OM, assessed by DNA microarray. Genes involved in JNK signaling regulation. The genes encoding JNK1 and JNK2 were modestly regulated by NTHi infection. Jnk1 was up-regulated for the first few days of OM, while Jnk2 exhibited down-regulation 3-6 hours after inoculation, followed by up-regulation on subsequent days. In contrast, many of the genes up- and down-stream of JNK were strongly regulated. The up-stream JNK activator genes Cdc42, Rac2 and Arrb2, and the down-stream target genes cJun, Stat3 and Stat4, and the negative regulator genes Dusp16 and Cdc42ep2 were rapidly and persistently up-regulated. *P <0.05, **P <0.01, ***P <0.001, compared to 0 hour expression.