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Figure 4 | BMC Immunology

Figure 4

From: C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media

Figure 4

Middle ear histology. Representative micrographs of the ME mucosal response to nontypeable Haemophilus influenzae (NTHi) in C57BL/6 (WT) mice, JNK1-/- mice, and JNK2-/- mice. Prior to infection (0d), the MEs of WT mice have a thin, simple mucosal layer consisting of a simple, squamous epithelium and minimal stroma. In contrast, 1-2 days after infection, the mucosa significantly thickens due to expansion of the stroma and hyperplasia of the mucosa into a columnar form. From 3-5 days, the WT mucosa essentially returns to baseline condition. Prior to infection, the JNK1-/- ME also exhibits a simple mucosa, which thickens considerably in the initial days after infection. However, the mucosa remains substantially hyperplasic through 7 days after infection. Prior to infection, JNK2-/- MEs also have a normal-appearing mucosa, and similar to JNK1-/- mice exhibit prolonged hyperplasia. However, JNK2-/- mice displayed a second peak of hyperplasia 7 days after infection, prior to recovering to normal thickness by 10-14 days. Bar =50 m.

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