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Figure 3 | BMC Immunology

Figure 3

From: Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

Figure 3

Qualitative analysis of ANAs in RIIB−/−and SLAM129mice. (A) Classification of staining profiles of HEp-2 cells. Representative staining patterns observed for serum samples from RIIB−/−SLAM129 mice are shown as fluorescently stained cells. (B) The classification of HEp-2 cell staining pattern and the related antibodies and diseases. (C, Upper) Comparison of the HEp-2 staining patterns of female RIIB−/− mice at different ages. The staining patterns were divided into six categories as shown in (B). (C, Lower) Comparison of the staining patterns between female RIIB−/− and SLAM129 mice at 24 weeks of age. For classification, staining profiles in sera from ≥13 mice were evaluated. Ho, homogeneous; Pe, peripheral; Cen, centromere; Sp, speckled; Nuc, nucleolar; etc, others. Significantly different between RIIB−/− and SLAM129 (P <0.0001 by Chi-square test).

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BMC Immunology

ISSN: 1471-2172

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