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Figure 4 | BMC Immunology

Figure 4

From: Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis

Figure 4

Increase of anti-DNA antibodies in RIIB−/−mice. (A) Anti-ssDNA (upper) and -dsDNA (lower) antibody levels in sera from female and male RIIB−/− mice, and female B6 mice at different ages. Anti-DNA levels were measured by ELISA and presented as values relative to that in a 12-month-old NZB/W F1 control female mouse, whose anti-dsDNA and anti-ssDNA levels were 6.64 g/ml and 4.69 g/ml, respectively. Each data point represents the mean value±SD (n ⁥3). Significantly different between female RIIB-/- and B6 (*P <0.05) with Student’s t-test. (B-D) Anti-DNA antibody (B, D) levels and ANA levels (C) in sera from female and male RIIB−/−SENDAI or TACONIC mice, RIIB−/−SLAM129, and B6 mice at different ages. Anti-DNA levels and ANAs were measured by ELISA and HEp-2 staining combined with ELISA, respectively, and presented as values relative to that in a 12-month-old NZB/W F1 control female mouse as described in A. Each data point represents the mean value±SD (n ≥3). *P <0.05. Student’s t-test. In B, the plots for RIIB−/− and B6 mice in A were superimposed for comparison. In D, the plots for RIIB−/−SLAM129 and B6 mice in B and A, respectively, were superimposed for comparison.

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